Results 141 to 150 of about 292,424 (340)

A third gene affecting GABA transaminase levels inAspergillans nidulus [PDF]

, 1980
Christopher R. Bailey, Herbert N. Arst, Hugh A. Penfold   +2 more
openalex   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Substitution of glutamine for lysine at the pyridoxal phosphate binding site of bacterial D-amino acid transaminase. Effects of exogenous amines on the slow formation of intermediates.

, 1990
Shiroh Futaki, Hiroshi Ueno, Álvaro Martínez‐del‐Pozo, Maria A. Pospischil, James M. Manning, Dagmar Ringe, Barry Stoddard, Katsuyuki Tanizawa, Tohru Yoshimura, K. Soda   +9 more
openalex   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Supplementary Figure 2 from Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV Cirrhosis with Normal Alanine Transaminase

, 2023
Ju Dong Yang, Jianliang Dai, Amit G. Singal, Purva Gopal, Benyam D. Addissie, Mindie H. Nguyen, Alex S. Befeler, K. Rajender Reddy, Myron Schwartz, Denise M. Harnois, Hiroyuki Yamada, Gregory J. Gores, Ziding Feng, Jorge A. Marrero, Lewis R. Roberts   +14 more
openalex   +1 more source

Associations between serum ferritin, iron, and liver transaminases in adolescents: a large cross-sectional study [PDF]

, 2023
Jialong Pan, Yonghua Liao, Qing Huang, Guoye Ji, Rujun Dai, Dongyun Lin   +5 more
openalex   +1 more source

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

EFFICACY OF SALICYLIC AND ASCORBIC ACIDS TO REDUCE THE EFFECT OF TRANSPORT STRESS ON LIVE WEIGHT, SOME BLOOD CHARACTERISTICS AND INTESTINAL VILLI OF BROILER CHICKENS

The Iraqi Journal of Agricultural science, 2020
This experiment was conducted and aimed to reducing mortality and losing the weight of birds transported to the slaughter house through reducing or Transport stress removal and thus to reduce financial losses.
Al obaydy & et al.
doaj  

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source