Results 11 to 20 of about 292,424 (340)

A dog model for acetaminophen-induced fulminant hepatic failure. [PDF]

, 1989
The development of a large animal model of fulminant hepatic failure produced with acetaminophen that should be useful in the development and evaluation of potential medical therapies for the important clinical problem of fulminant hepatic failure is ...
Barone, M, Demetris, J, Francavilla, A, Makowka, L, Polimeno, L, Prelich, J, Starzl, TE, Van Thiel, DH   +7 more
core   +1 more source

Enhancing PLP-Binding Capacity of Class-III ω-Transaminase by Single Residue Substitution

Frontiers in Bioengineering and Biotechnology, 2019
Transaminases are pyridoxal-5′-phosphate (PLP) binding enzymes, broadly studied for their potential industrial application. Their affinity for PLP has been related to their performance and operational stability and while significant differences in PLP ...
David Roura Padrosa, Raphael Alaux, Phillip Smith, Ingrid Dreveny, Fernando López-Gallego, Fernando López-Gallego, Francesca Paradisi, Francesca Paradisi   +7 more
doaj   +1 more source

Detoxification of Fumonisins by Three Novel Transaminases with Diverse Enzymatic Characteristics Coupled with Carboxylesterase

Foods, 2023
Fumonisin (FB) is one of the most common mycotoxins contaminating feed and food, causing severe public health threat to human and animals worldwide.
Yue Wang, Junhao Sun, Mengwei Zhang, Kungang Pan, Tianhui Liu, Tongcun Zhang, Xuegang Luo, Junqi Zhao, Zhongyuan Li   +8 more
doaj   +1 more source

Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative surgery for colon cancer [PDF]

, 2009
<b>Aim</b>: To comprehensively compare the prognostic value of tumour and patient-related factors in patients undergoing curative surgery for colon cancer.
Benson, Brown, Compton, Cooper, Crozier, Dukes, Forrest, Gabay, Gasser, Halazun, Hauser, Ishizuka, Kacevska, Kandemir, Kim, Kobayashi, Lee, Leitch, Lindmark, Maltoni, McMillan, McMillan, Mehrkhani, Michael, Moertel, Monreal, Morris, Petrelli, Ramsey, Roxburgh, Sasaki, Sharma, Smith, Taylor, Thynne, Vakkila, Vibert, Viganó, Walsh, Wanebo, Wang, Wolpin   +41 more
core   +1 more source

A Puzzling Protein from Variovorax paradoxus Has a PLP Fold Type IV Transaminase Structure and Binds PLP without Catalytic Lysine

Crystals, 2022
Effective biocatalysts for the synthesis of optically pure amines from keto precursors are highly required in organic synthesis. Transaminases are a large group of PLP-dependent enzymes, which can be utilized for production of chiral amines or amino ...
Konstantin M. Boyko, Ilya O. Matyuta, Alena Y. Nikolaeva, Tatiana V. Rakitina, Vladimir O. Popov, Ekaterina Yu. Bezsudnova, Maria G. Khrenova   +6 more
doaj   +1 more source

Effect of anti-retroviral therapy on oxidative stress in hospitalized HIV-infected adults with and without TB. [PDF]

, 2018
BackgroundHIV infection and opportunistic infections cause oxidative stress (OS), which is associated with tissue damage. Anti-retroviral therapy (ART) is used to treat HIV and decrease the risk of opportunistic infections, but it is unclear whether ART ...
Andama, Alfred, Bukenya, Andrew, Byanyima, Patrick, Davis, J Lucian, Huang, Laurence, Kaswabuli, Sylvia, Matovu, Denis Kasozi, Mayanja-Kizza, Harriet, Musisi, Emmanuel, Sanyu, Ingvar, Seremba, Emmanuel, Sessolo, Abdul, Walter, Nicholas D, Worodria, William, Zawedde, Josephine   +14 more
core   +3 more sources

Efficacy of Heptral® in the treatment of hepatic toxicity induced by cytostatic chemotherapy

Опухоли женской репродуктивной системы, 2014
The efficacy of Heptral® (ademethionine) was evaluated in the treatment of chemotherapy-induced hepatotoxicity in 19 patients with various malignancies.
A. V. Snegovoy, L. V. Manzyuk
doaj   +1 more source

Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019) [PDF]

, 2019
The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities.
Alcántara, Andrés R., Domínguez de María, Pablo, Gonzalo Calvo, Gonzalo de   +2 more
core   +3 more sources

Hypoalbuminaemia predicts outcome in adult patients with congenital heart disease [PDF]

, 2015
Background In patients with acquired heart failure, hypoalbuminaemia is associated with increased risk of death. The prevalence of hypoproteinaemia and hypoalbuminaemia and their relation to outcome in adult patients with congenital heart disease (ACHD ...
Alonso-Gonzalez, R, Diller, G-P, Dimopoulos, K, Donovan, J, Gatzoulis, MA, Hooper, J, Kempny, A, Li, W, Rafiq, I, Swan, L, Uebing, A, Wort, SJ   +11 more
core   +1 more source

Development of a decision support tool for primary care management of patients with abnormal liver function tests without clinically apparent liver disease: a record-linkage population cohort study and decision analysis (ALFIE)

Health Technology Assessment, 2009
Objectives: To determine the natural history of abnormalities in liver function tests (LFTs), derive predictive algorithms for liver disease and identify the most cost-effective strategies for further investigation.
PT Donnan, D McLernon, JF Dillon, S Ryder, P Roderick, F Sullivan, W Rosenberg   +6 more
doaj   +1 more source