Results 261 to 270 of about 292,424 (340)

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

Isolated IgG elevation in patients with persistently normal transaminases does not affect the outcome of autoimmune hepatitis. [PDF]

JHEP Rep
Díaz-González Á, Schregel I, Carballo L, Álvarez-Navascués C, Frisancho-Morales E, Miquel M, Retortillo MG, Gómez J, Horta D, Mateos B, Engel B, Volmer F, Barrio MD, Rodríguez-Tajes S, Olivas I, Hartl J, González CA, Hernández-Guerra M, Castello I, Pérez-Medrano I, González-Santiago JM, Arencibía A, Gómez A, Rodríguez-Perálvarez M, Crespo J, Sala M, Salcedo M, Barreira-Díaz A, Riveiro-Barciela M, Taubert R, Schramm C, Londoño MC, ColHai Registry.   +32 more
europepmc   +1 more source

ABNORMAL INCREASES OF THE TRANSAMINASE LEVEL IN PREGNANT WOMEN WITH COMPLICATED COURSES OF CHOLESTASIS PREGNANCY

, 2018
O. V. Kosheleva, M. A. Kachkovskiy
openalex   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Biocatalytic cascade combining an engineered pyranose 2-oxidase and transaminases for the synthesis of amino sugars. [PDF]

RSC Adv
Chuaboon L, Visitsatthawong S, Sookbampen O, Suthin S, Voss M, Wongnate T, Höhne M, Bornscheuer UT, Chaiyen P.   +8 more
europepmc   +1 more source

Alteration of Enzyme Aspartate Transaminase in Goat Milk related to Udder health status

, 2009
S. W. Bonde, Malyutina Katerina V., Khodke, R. B.   +3 more
openalex   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Erythrosine-induced hepatic biomarkers and histopathological changes in male rats: protective effects of lycopene and anthocyanin. [PDF]

Front Pharmacol
Qahl SH, Alqahtani FA, Al-Nahari H, Alghamdi FA, Khouja FH, Khouja AH.   +5 more
europepmc   +1 more source

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source