Results 91 to 100 of about 114,148 (343)

Impact of donor transaminases on liver transplant utilisation and unnecessary organ discard: national registry cohort study

Frontiers in Transplantation
BackgroundDonor liver transaminases (ALT and AST) have been used to decline livers for transplant, despite evidence that they do not influence transplant outcomes.
Joseph J. Dobbins, Samuel J. Tingle, Samuel J. Tingle, Jennifer Mehew, Emily R. Thompson, Emily R. Thompson, Georgios Kourounis, Georgios Kourounis, Stuart McPherson, Steve A. White, Steve A. White, Colin H. Wilson, Colin H. Wilson   +12 more
doaj   +1 more source

Ornithine Transaminase [PDF]

Nature, 1951
J H, QUASTEL, R, WITTY
openaire   +2 more sources

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Bioprospecting Reveals Class III ω-Transaminases Converting Bulky Ketones and Environmentally Relevant Polyamines

Applied and Environmental Microbiology, 2018
Amine transaminases of the class III ω-TAs are key enzymes for modification of chemical building blocks, but finding those capable of converting bulky ketones and (R) amines is still challenging. Here, by an extensive analysis of the substrate spectra of
C. Coscolín, Nadine Katzke, A. García-Moyano, J. Navarro-Fernandez, David Almendral, M. Martínez‐Martínez, A. Bollinger, R. Bargiela, C. Gertler, T. Chernikova, D. Rojo, C. Barbas, Hai Tran, O. Golyshina, R. Koch, M. Yakimov, G. Bjerga, P. Golyshin, K. Jaeger, M. Ferrer   +19 more
semanticscholar   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Discovery of biophysical rate laws from the electronic health record enables real-time liver injury estimation from transaminase dynamics

Cell Reports Medicine
Summary: Alanine (ALT) and aspartate (AST) aminotransferases are standard-of-care biomarkers for liver injury though their temporal dynamics during injury and resolution remain incompletely characterized.
Marc S. Sherman, Wolfram Goessling
doaj   +1 more source

A metagenomics approach for new biocatalyst discovery: application to transaminases and the synthesis of allylic amines

, 2017
Transaminase enzymes have significant potential for the sustainable synthesis of amines using mild aqueous reaction conditions. Here a metagenomics mining strategy has been used for new transaminase enzyme discovery.
D. Baud, J. W. E. Jeffries, T. Moody, J. Ward, H. Hailes   +4 more
semanticscholar   +1 more source

Characterization and evaluation of liver fibrosis grade in patients with chronic hepatitis B virus infection and normal transaminases

Clinical and Molecular Hepatology, 2018
Background/Aims The objective of our study was to determine the epidemiological, laboratory, and serological characteristics of patients with chronic hepatitis B virus (HBV) infection and normal transaminases.
S. Cristina, Casado Marta, G. Mercedes, Porcel Martín Almudena, H. Álvaro, Vega‐Baez Jose Luis, Parrón Carreño Tesifón   +6 more
semanticscholar   +1 more source

METTL1‐Mediated M7G tRNA Modification Promotes Residual Liver Regeneration After Hepatectomy via Translational Control

Advanced Science, EarlyView.
METTL1 and its mediated m7G tRNA modification are significantly up‐regulated after partial hepatectomy (PHx). Overexpression of METTL1 improves the efficiency of liver regeneration after PHx, increases the proliferation of hepatocytes, and accelerates the recovery of liver function.
Manling Huang, Shuirong Lin, Yutong Zhao, Jiale Chen, Linyuan Huang, Yuyao Liu, Zixin Huang, Dongxin An, Yifan Zhang, Zimin Song, Xi Yu, Yunpeng Hua, Jing Wang, Weiwei Wang, Yu Guo, Ming Kuang, Fang Wang, Shuibin Lin, Shunli Shen   +18 more
wiley   +1 more source

Discovery and structural characterisation of new fold type IV-transaminases exemplify the diversity of this enzyme fold

Scientific Reports, 2016
Transaminases are useful biocatalysts for the production of amino acids and chiral amines as intermediates for a broad range of drugs and fine chemicals.
T. Pavkov-Keller, Gernot A. Strohmeier, M. Diepold, W. Peeters, Natascha Smeets, Martin Schürmann, K. Gruber, H. Schwab, K. Steiner   +8 more
semanticscholar   +1 more source