Results 101 to 110 of about 114,148 (343)

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Monitoramento de eletrólitos, de marcadores de danos musculares e função renal em atletas de Futebol de Elite

Revista Brasileira de Nutrição Esportiva, 2018
O monitoramento de marcadores bioquímicos é necessário para conhecer o estado orgânico de atletas diante da rotina extenuante de treinamento e competição.
Bruna Krefta, Caroline Vechi, Flavia Gabriela Pinezi, Thais Regina Mezzomo   +3 more
doaj  

The influence of mountain papaya and bitter melon extract supplementation on aspartate transaminase enzyme in diabetic rats models

, 2021
Heru Sasongko, A N Shofa, Natasya Advaita   +2 more
openalex   +1 more source

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

Advanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi, Minmin Wu, Jinwei Zhong, Chao Chen, Zhuang Huang, Jingxuan Peng, Dong Yang, Xingjie Zan, Zhengfei Wang   +8 more
wiley   +1 more source

Gallium‐Doped MXene Nanozymes Protect Liver Through Multi‐Death Pathway Blockade and Hepatocyte Regeneration

Advanced Science, EarlyView.
This study develops gallium‐doped V2C MXene nanozymes (Ga‐V2C) to treat acetaminophen‐induced liver injury through multi‐death pathway blockade and hepatocyte regeneration. Unlike conventional single‐target therapies like N‐acetylcysteine, Ga‐V2C nanozymes enable oxidative stress suppression, apoptosis, and ferroptosis inhibition, and enhanced ...
Xiaopeng Cai, Jingwen Deng, Liqing Wang, Junjie Su, Dongyi Xian, Yilang Yan, Xinyu Yang, Chuanbin Wu, Tingting Peng, Yuan Ding, Guilan Quan, Weilin Wang, Min Zhou, Chao Lu   +13 more
wiley   +1 more source

Changes in perioperative serum transaminase levels: predicting early recurrence after hepatectomy for hepatocellular carcinoma

Frontiers in Oncology
Background and purposeHepatocellular carcinoma (HCC) is associated with poor prognosis due to its high propensity for early postoperative recurrence.
Yingfei Wei, Guixiang Qian, Tao Meng, Zhong Tong   +3 more
doaj   +1 more source

Evolutionary Diversification of Alanine Transaminases in Yeast: Catabolic Specialization and Biosynthetic Redundancy

Frontiers in Microbiology, 2017
Gene duplication is one of the major evolutionary mechanisms providing raw material for the generation of genes with new or modified functions. The yeast Saccharomyces cerevisiae originated after an allopolyploidization event, which involved mating ...
Ximena Escalera-Fanjul, Carlos Campero-Basaldua, Maritrini Colón, James González, Dariel Márquez, Alicia González   +5 more
semanticscholar   +1 more source

In type 1 autoimmune hepatitis (AIH), should remission be redefined as normalization of transaminases? [PDF]

, 2006
Sumita Verma
openalex   +1 more source

Redox‐Responsive Tellurium‐Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy

Advanced Science, EarlyView.
This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However,
Jing Xue, Jialu Zhuang, Taotao Fan, Songtao Tang, Junjun Wang, Xiaohui Liu, Jian Liu, Jin Shi, Jiaji Li, Wanjun Li, Danyou Hu, Xiaoqian Zhang, Hua Wang, Guiyang Zhang   +13 more
wiley   +1 more source

A New Paradigm in Gallstones Diseases and Marked Elevation of Transaminases: An Observational Study.

Annals of Hepatology, 2017
BACKGROUND In clinical practice, it is assumed that a severe rise in transaminases is caused by ischemic, viral or toxic hepatitis. Nevertheless, cases of biliary obstruction have increasingly been associated with significant hypertransaminemia.
Sara Campos, Nuno Silva, A. Carvalho
semanticscholar   +1 more source