Results 161 to 170 of about 137,846 (394)

Identification of novel small molecule inhibitors of adenovirus gene transfer using a high throughput screening approach [PDF]

, 2013
Due to many favourable attributes adenoviruses (Ads) are the most extensively used vectors for clinical gene therapy applications. However, following intravascular administration, the safety and efficacy of Ad vectors are hampered by the strong hepatic ...
Alan L. Parker, Alba, Alba, Andrew H. Baker, Aplander, Bleicher, Bradshaw, Carlisle, Di Paolo, Dmitriev, Dmytro Kovalskyy, Doronin, Duffy, Duffy, Edelstein, Eric R. Kalkman, Gillard, Huard, Jiang, Kalyuzhniy, Katie White, Lagunin, Lieber, Lyons, Majhen, Margaret R. Duffy, Nilsson, Ortigoza, Othman, Parker, Sharon M. Kelly, Spjut, Stone, Von Seggern, Waddington, Xu, Zhang   +36 more
core   +1 more source

piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization

Advanced Science, EarlyView.
PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, have been implicated in the development of various diseases. This study explores the tumor‐suppressive mechanism of a downregulated piRNA (designated piR‐RCC) in renal cell carcinoma (RCC), and provides a delivery strategy targeting RCC tumor by constructing a cell membrane ...
Ruyue Wang, Fan Li, Yudong Lin, Zeyi Lu, Wenqin Luo, Zhehao Xu, Ziwei Zhu, Yi Lu, Xudong Mao, Yang Li, Zhinian Shen, Haohua Lu, Yining Chen, Liqun Xia, Mingchao Wang, Lifeng Ding, Gonghui Li   +16 more
wiley   +1 more source

Influence of Hyperhomocysteinemia Correction on Functional Liver Tests and Lipid Profile in Patients with Nonalcoholic Fatty Liver Disease in Combination with Type 2 Diabetes Mellitus

Mìžnarodnij Endokrinologìčnij Žurnal, 2015
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM) are the components of metabolic syndrome, the incidence of which is increasing in the world every year.
V.F. Orlovskyi, N.H. Kuchma
doaj   +1 more source

Effects of amino acids on transaminase production in Neurospora crassa: evidence for four different enzymes [PDF]

, 1956
J. R. S. Fincham, A. B. Boulter
openalex   +1 more source

Genomic and Cis‐Regulatory Basis of a Plastic C3‐C4 Photosynthesis in Eleocharis Baldwinii

Advanced Science, EarlyView.
The sedge Eleocharis baldwinii remarkably switches between C3‐like and C4‐like photosynthesis in response to environmental conditions. Combining gap‐free genome assembly with single‐cell multi‐omics, this study uncovers how subgenome dominance and cell‐specific cis‐regulation enable C4 photosynthesis.
Lu Chen, Yanfeng Jia, Zaihui Zhou, Qiying Jiang, Jianlin Liu, Jianhui Gu, Chuan Chen, Shujing Cheng, Jinfang Chu, Xin Liu, Yongjun Lin, Xiang Li   +11 more
wiley   +1 more source

Combining Aldolases and Transaminases for the Synthesis of 2‑Amino-4-hydroxybutanoic Acid

, 2017
Amino acids are of paramount importance as chiral building blocks of life, for drug development in modern medicinal chemistry, and for the manufacture of industrial products.
K. Hernández, J. Bujons, J. Joglar, S. Charnock, P. D. María, W. Fessner, P. Clapés   +6 more
semanticscholar   +1 more source

A new target region for changing the substrate specificity of amine transaminases

Scientific Reports, 2015
(R)-stereospecific amine transaminases (R-ATAs) are important biocatalysts for the production of (R)-amine compounds in a strict stereospecific manner.
L. Guan, J. Ohtsuka, M. Okai, T. Miyakawa, Tomoko Mase, Yuehua Zhi, F. Hou, Noriyuki Ito, A. Iwasaki, Y. Yasohara, M. Tanokura   +10 more
semanticscholar   +1 more source

Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation

Advanced Science, EarlyView.
Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu, Tong Ji, Zhichao Ye, Jianing Yan, Chao Wang, Jiachen Chen, Ziyang Jin, Yongji Zhu, Xiujun Cai, Yifan Wang   +9 more
wiley   +1 more source

OCCURRENCE OF ORNITHINE δ-TRANSAMINASE: A DICHOTOMY [PDF]

, 1957
William Scher, Henry J. Vogel
openalex   +1 more source

Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime

Advanced Science, EarlyView.
A hollow nanomotor (PM‐HMSN/Arg) propelled by ultrasound‐triggered nitric oxide (NO) was developed. The nanomotor employs a “tethering‐relaxing‐drilling” mechanism to overcome biological barriers, enabling multimodal theranostics of cancer with deep penetration and extended lifetime.
Xue Xu, Jinxu Cao, Yan Mu, Hao Zhang, Ya‐Lei Wang, Mengzhen Chen, Yuce Li, Qian Hua   +7 more
wiley   +1 more source