Results 191 to 200 of about 122,944 (342)

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Endothelial injury is a central driver of systemic IFN-β toxicity and is reversible through Jak inhibition. [PDF]

Mol Ther Oncol
Zhang L, Pham L, Steele MB, Jenks N, Nace R, Russell SJ, Peng KW.   +6 more
europepmc   +1 more source

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, EarlyView.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source

Association Between Waist Circumference to Body Mass Index Ratio and Elevated Serum Transaminases Among Patients on Dolutegravir-based Antiretroviral Therapy in South Western Uganda. [PDF]

J Int Assoc Provid AIDS Care
Bagenda CN, Kisakye P, Mudondo H, Nantongo C, Malinga MK, Kigenyi C, Nanyijuka I, Ainebyona A, Tumusiime J, Mugisa MJ, Ssemwanga E, Ampaire L, Mwesigye V, Tusubira D, Rugera SP.   +14 more
europepmc   +1 more source

Engineered Au@CeO2 Hybrid Nanoparticles With Microenvironment Dependent Self‐Adjustability for Integration of Tumor‐Specific Photothermal‐Chemodynamic Therapy and Inflammation Prevention

Advanced Science, EarlyView.
An intelligent Au@CeO2 Hybrid Nanoparticles (ACEF) with microenvironment‐dependent self‐adjustability was engineered to not only perform efficient and tumor‐specific photothermal‐chemodynamic therapy for precise tumor elimination, but also serve as a ROS scavenger in healthy tissues around the tumor to avoid the unexpected oxidative damage and ...
Wenyun Mu, Wenjuan Tang, Handan Zhang, Jie Liu, Jiaqi Zhang, Yu Yao, Xiao Fu, Xin Chen, Yanmin Zhang   +8 more
wiley   +1 more source

A novel compound heterozygous NBAS variant with HLH and multisystem involvement: expanding the clinical spectrum and literature review. [PDF]

Front Immunol
Gong X, Feng Y, Zhang Q, Tong L, Feng Z, Zhao X, Zhou L, Dou Y.   +7 more
europepmc   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Harnessing Bacillus inaquosorum AGSP2 for enhancing ω-transaminase production through classical and AI-supported statistical design. [PDF]

Sci Rep
Pandya S, Chhaya U, Gupte A.
europepmc   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Stabilization of Transaminases in Aqueous-Organic Media by Pyridoxal-5'-phosphate: A Case Study of Transaminase from Desulfomonile tiedjei. [PDF]

Acta Naturae
Rudina IV, Bakunova AK, Popov VO, Bezsudnova EY.   +3 more
europepmc   +1 more source