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Serum transaminases in kwashiorkor
The Journal of Pediatrics, 1962Determinations of serum glutamic oxaloacetic and glutamic pyruvic transaminases in children with kwashiorkor failed to show differences between children with “serious” or “early” disease; there was also no change in the concentration of the enzymes after 3 weeks of treatment.
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Nature, 1952
IT has previously been reported by Cohen1 that enzyme preparations catalysing the reactions : (1) Alanine + α-ketoglutarate ⇌ glutamate + pyruvate; (2) Aspartate + α-ketoglutarate ⇌ glutamate + oxalo acetate; are also capable of catalysing : (3) Cysteic acid + α-ketoglutarate ⇌ glutamate + sulphopyruvate.
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IT has previously been reported by Cohen1 that enzyme preparations catalysing the reactions : (1) Alanine + α-ketoglutarate ⇌ glutamate + pyruvate; (2) Aspartate + α-ketoglutarate ⇌ glutamate + oxalo acetate; are also capable of catalysing : (3) Cysteic acid + α-ketoglutarate ⇌ glutamate + sulphopyruvate.
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1979
In summary, several branched-chain fatty acids appeared to be competitive inhibitors of GABA-T and non-competitive inhibitors of SSADH. These compounds produce an increase in brain GABA level, and for two of these it was shown that the increase differs among various brain areas. An increase of GABA cannot be obtained by inhibition of SSADH.
L, Ciesielski +8 more
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In summary, several branched-chain fatty acids appeared to be competitive inhibitors of GABA-T and non-competitive inhibitors of SSADH. These compounds produce an increase in brain GABA level, and for two of these it was shown that the increase differs among various brain areas. An increase of GABA cannot be obtained by inhibition of SSADH.
L, Ciesielski +8 more
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Structural insight into the substrate specificity of PLP fold type IV transaminases
Applied Microbiology and Biotechnology, 2020Konstantin Boyko +2 more
exaly
Shifting the pH Optima of (R)-Selective Transaminases by Protein Engineering
International Journal of Molecular Sciences, 2022Matthias Höhne +2 more
exaly