Results 241 to 250 of about 114,148 (343)

Catalytic Promiscuity of Transaminases: Preparation of Enantioenriched β-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination.

Angewandte Chemie, 2016
A. Cuetos, Marina García‐Ramos, Eva-Maria Fischereder, A. Diaz‐Rodriguez, G. Grogan, V. Gotor, W. Kroutil, I. Lavandera   +7 more
semanticscholar   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Practical approach to the safe use of cannabidiol in patients with refractory epilepsy: a mini review. [PDF]

Front Pharmacol
Navarro CE.
europepmc   +1 more source

The Interaction of Cycloserine with Glutamate Aspartate Transaminase as Measured by Fluorescence Spectroscopy

, 1967
Jorge E. Churchich
openalex   +1 more source

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source

Biomimetic Iridium‐Based Photothermal Nanozyme to Trigger Ferroptosis and Pyroptosis and Activate the cGAS‐STING Pathway for Improved Tumor Immunotherapy

Advanced Science, EarlyView.
This study develops an iridium‐based nanozyme (IIN@M) with superior enzyme‐like activity and photothermal performance. It disrupts intracellular redox balance by generating reactive oxygen species and depleting glutathione, which synergistically induces ferroptosis, pyroptosis, and immunogenic cell death.
Lijun Ding, Zhongxiong Fan, Guoyu Xia, Fukai Zhu, Nan Yang, Shujie Yu, Longlong Yuan, Jinyao Li   +7 more
wiley   +1 more source

High prevalence of dengue with warning signs but absence of severe cases in Vietnamese pediatric patients: an analysis of predictive factors. [PDF]

Infez Med
Le NQ, Nguyen HA, Vu KH, Dang KL, Hoang NT, Dao TL, Hoang VT.   +6 more
europepmc   +1 more source

Efek ekstrak daun krokot (portulaca oleracia L.) terhadap kadar alanin transaminase (ALT) tikus putih (rattus nuovegicus) yang diberi minyak goreng deep frying [PDF]

, 2010
Farah Maulida
openalex  

Evaluation of serum transaminase level as diagnostic tool for assessing hepatic disease conditions among chronic hepatitis B patients in Bangladesh

, 2018
Fahmi Md Shaief, SM Sabbir Alam, Md Shahinul Alam, Mahmuda Yasmin, CR Ahsan, Jamalunnessa   +5 more
openalex   +2 more sources

Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors

Advanced Science, EarlyView.
Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu, WeiYi Cheng, Menghang Yang, Li He, WeiYe Ren, JingQuan Chen, LiTing He, Dandan Bao, Zhihong Zhu, Lixin Wang, Qinghua Yao, Ji‐Gang Piao   +11 more
wiley   +1 more source