Results 241 to 250 of about 50,464 (295)

Protective effects of allicin against stanozolol‐induced cardiotoxicity: Physiological and histopathological evidence in a rabbit model

Animal Models and Experimental Medicine, EarlyView.
There are many forms of anabolic steroids, including stanzolo (Winstrol), which are popular for their muscle‐building effects but dangerous to the heart. This present work is aimed at evaluating the pharmacological impact of allacin, a natural attribute obtained from garlic on obstructing cardiac injury in rabbits that received stanzolo.
Mohammed Hayder Asker, Noor AL‐Huda Salah AL‐Zuhairy, Wassan Mhammed Husain, Mustafa Riyadh Abdullah   +3 more
wiley   +1 more source

Metabolic-Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel Therapies. [PDF]

Int J Hepatol
Cooper J, Patel P, Tristeza J, Yang A.
europepmc   +1 more source

Long‐term immunosuppression of rabbits through oral tacrolimus administration

Animal Models and Experimental Medicine, EarlyView.
Oral gavage of rabbits with 1.5 mg/kg/d of tacrolimus allows for an efficient long‐term (1 year) immunosuppression with minimal side effects and no loss of animals. lmmunosuppressed rabbits are a convenient animal model to investigate the long‐term efficacy of human allografts in vivo.
Alexane Thibodeau, Todd Galbraith, Oumayma Hayouni, Hélène T. Khuong, François Berthod   +4 more
wiley   +1 more source

Management of dyslipidaemia in patients with comorbidities-facing the challenge. [PDF]

Eur Heart J Cardiovasc Pharmacother
Frühwald L, Fasching P, Dobrev D, Kaski JC, Borghi C, Wassmann S, Huber K, Semb AG, Agewall S, Drexel H.   +9 more
europepmc   +1 more source

Achieving scalable expansion of therapeutic porcine hepatocytes in vivo through serial transplantation

Animal Models and Experimental Medicine, EarlyView.
This represents the first serial hepatocyte transplantation pig model designed to investigate the massive hepatocyte proliferation in vivo. Leveraging this novel model, we achieved serial hepatocyte transplantation and regeneration in a porcine model, where the transplanted hepatocytes effectively repopulated the livers of two‐generation model pigs in ...
Zhiqiang Han, Xin Wang, Dawei Yu, Jing Wang, Ke Sun, Siqi Wang, Ying Zhang, Guihai Feng, Wei Li, Tang Hai, Jilong Ren   +10 more
wiley   +1 more source

Functional and structural insights into a thermostable (S)-selective amine transaminase and its improved substrate scope by protein engineering

Patti S, Rose SA, Isupov MN, Alunno IM, Riva S, Ferrandi EE, Littlechild JA, Monti D.   +7 more
europepmc   +1 more source

Understanding antituberculosis drug-induced hepatotoxicity: Risk factors and effective management strategies in the pediatric population. [PDF]

World J Clin Pediatr
Semwal P, Saini MK, Sarma MS.
europepmc   +1 more source

Cationic Nanoparticles Mitigate Chemotherapy‐Induced Peripheral Neuropathy

Advanced NanoBiomed Research, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN), caused by chemodrugs like paclitaxel (PTX), leads to severe neuropathic pain. This study evaluates PTX‐loaded PAMAM‐Chol nanoparticles (PTX‐NPs) to alleviate CIPN. PTX‐NPs achieve 99% drug‐loading efficiency, reduce neurotoxicity, and in murine models, decrease cold allodynia by 85% while restoring ...
Divya Bhansali, Rocco Latorre, Raquel Tonello, David Poolman, Suwan Ding, Brian L. Schmidt, Nigel W. Bunnett, Kam W. Leong   +7 more
wiley   +1 more source

Diagnosis, management and prevention of loiasis: guideline of the German Society for Tropical Medicine, Travel Medicine, and Global Health (DTG). [PDF]

Infection
Ramharter M, Schlabe S, Hübner MP, Michelitsch P, Kurth F, Bélard S, Nordmann T, Davi SD.   +7 more
europepmc   +1 more source

Tuning Cellular Perception in Pluripotent Stem Cells through Topography, Stiffness, and Patterning

Advanced NanoBiomed Research, EarlyView.
Micro‐ and nanotopographical cues, substrate stiffness, and mechanical patterning synergistically direct pluripotent stem cell fate and function by tuning cellular perception at the biointerface. Pluripotent stem cells (PSCs), comprised of embryonic stem cells and induced PSCs, hold tremendous therapeutic potential.
Yuan Jiang, Jann Harberts, Yaping Chen, Richard J. Williams, Wei Duan, Rasika M. Samarasinghe, Nicolas H. Voelcker, Roey Elnathan   +7 more
wiley   +1 more source