Results 51 to 60 of about 26,501 (228)

Regional transarterial chemoembolization combined with chemoradiotherapy for locally advanced rectal cancer: a retrospective study of a new combination

Frontiers in Oncology, 2023
ObjectivesLocally advanced rectal cancer (LARC) has a high risk of distant metastasis (DM). Currently, many treatment courses of LARC have arisen, but patients’ DM status has not significantly improved.
Wen-Jun Meng, Chun-Hua Liu, Ru-Jun Zheng, Chun-Xue Li   +3 more
doaj   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Modified transarterial chemoembolization with locoregional administration of sorafenib for treating hepatocellular carcinoma: feasibility, efficacy, and safety in the VX-2 rabbit liver tumor model [PDF]

, 2016
PURPOSE:We aimed to assess the feasibility, efficacy and safety of a local application of sorafenib within a conventional transarterial chemoembolization in the VX-2 tumor-bearing rabbit model.METHODS:VX-2 tumors were induced in the left liver lobe of 10
Jan Brauner, Christian Wybranski, Nadine Schulz, Thomas Kalinski, Ricarda Seidensticker, Benjamin Garlipp, Norbert Nass, Ingo Steffen, Sebastian Streit, Oliver Dudeck, Jens Ricke, Max Seidensticker, Julian Jürgens   +12 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

mRECIST criteria and contrast-enhanced US for the assessment of the response of hepatocellular carcinoma to transarterial chemoembolization

Diagnostic and Interventional Radiology, 2014
PURPOSEWe aimed to evaluate the combination of the modified Response Evaluation Criteria In Solid Tumors (mRECIST) and contrast-enhanced ultrasonography (CEUS) as a tool for the assessment of hepatocellular carcinoma treated with transarterial ...
Hippocrates Moschouris, Katerina Malagari, Marina G. Papadaki, Ioannis Kornezos, Konstantinos Stamatiou, Antonios Anagnostopoulos,, Katerina Chatzimichael, Nikolaos Kelekis   +7 more
doaj   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

Bridge Therapy before Liver Transplant for Advanced Hepatocellular Carcinoma

Medicina
Hepatocellular carcinoma is the most common primary liver tumor. Orthotopic liver transplant is one of the best treatment options, but its waiting list has to be considered. Bridge therapies have been introduced in order to limit this issue.
Valentina Bianchi, Erida Nure, Carmen Nesci, Marco Maria Pascale, Gabriele Sganga, Salvatore Agnes, Giuseppe Brisinda   +6 more
doaj   +1 more source

Mac‐2 Binding Protein Glycosylation Isomer (M2BPGi)–Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe, Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Tomoharu Yoshizumi   +8 more
wiley   +1 more source

Effect of Nursing Teaching Protocol on Patient Reported Outcomes among Hepatocellular Carcinoma Patients Undergoing Transarterial Chemoembolization [PDF]

Egyptian Journal of Health Care
Background: Transarterial chemoembolization is an effective therapy for liver malignancies that cannot be cured. Aim: Evaluate effect of nursing teaching protocol on patient-reported outcomes among hepatocellular carcinoma patients undergoing ...
Manal Sayed Atya, Kawther Badry Mobed, Attyiat Hassan Hussein, Sayed Hassan Ahmed   +3 more
doaj   +1 more source

Balloon-occluded chemoembolization for hepatocellular carcinoma: a prospective study of safety, feasibility and outcomes

Hepatic Oncology, 2021
Aim: Evaluation of safety and efficacy of selective balloon-occluded transarterial chemoembolization using polyethylene glycol embolizing microspheres in patients with hepatocellular carcinoma.
Ana-Maria Bucalau, Illario Tancredi, Martina Pezzullo, Raphael Leveque, Simona Picchia, Jean-Luc Van Laethem, Gontran Verset   +6 more
doaj   +1 more source