Results 141 to 150 of about 1,943 (192)
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Biochemical and Biophysical Research Communications, 1995
Human transcobalamin II (TC II) gene was isolated and partially sequenced. The gene is composed of nine exons and eight introns spanning approximately 20 kb. Multiple potential transcription start sites were revealed by primer extension analysis. The 5'-flanking region of the gene contained no TATA-like motif, but a binding motif for HIP1, which is ...
N, Li, S, Seetharam, B, Seetharam
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Human transcobalamin II (TC II) gene was isolated and partially sequenced. The gene is composed of nine exons and eight introns spanning approximately 20 kb. Multiple potential transcription start sites were revealed by primer extension analysis. The 5'-flanking region of the gene contained no TATA-like motif, but a binding motif for HIP1, which is ...
N, Li, S, Seetharam, B, Seetharam
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Expression of transcobalamin II by amniocytes
Prenatal Diagnosis, 1987AbstractChildren with a genetic absence of transcobalarnin 2 (TC2) are clinically asymptomatic at birth but develop severe megaloblastic anemia early in life. We have examined the incorporation of [57Co]‐CN‐B12 in the absence of any exogenous source of TC2 in control amniotic fluid derived cells and cultured diploid fibroblasts, and in fibroblasts from
D S, Rosenblatt, A, Hosack, N, Matiaszuk
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Allelic forms of mouse transcobalamin 2
Biochemical Genetics, 1982Transcobalamin 2 is the only vitamin B12-binding protein found in mouse serum. Two allelic forms of mouse transcobalamin 2 are described. The two forms differ in their mobilities on polyacrylamide gel electrophoresis. The slowly migrating form has been found in serum from 25 inbred mouse strains. The more rapidly migrating form was detected in 3 inbred
Frater, schroder M +4 more
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4 Transcobalamin II and the membrane receptor for the transcobalamin II-cobalamin complex
Baillière's Clinical Haematology, 1995Summary Transcobalamin II is a plasma protein that binds vitamin B 12 (cobalamin) as it is absorbed in the terminal ileum and distributes it to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of tissue cells and is then internalized by receptor-mediated endocytosis.
Sheldon P. Rothenberg, Edward V. Quadros
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Transcobalamins: Vitamin B12 Transport
1980In Volume 2 of this series, the transcobalamines were introduced, in connection with vitamin B12 function and transport (pp. 520–525). Here, a brief review will be given of this problem and of the developments which have taken place since this subject was discussed in Volume 2.
Samuel Natelson, Ethan A. Natelson
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The Journal of Pediatrics, 1972
Supplemental vitamin B 12 therapy, which was being administered to a child with hereditary transcobalamin II (TC II) deficiency, was temporarily discontinued in order to evaluate the role of TC II in vitamin B 12 -mediated reactions. Within six weeks the child developed megaloblastic anemia, thrombocytopenia, leukopenia, and granulocytopenia.
C R, Scott +3 more
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Supplemental vitamin B 12 therapy, which was being administered to a child with hereditary transcobalamin II (TC II) deficiency, was temporarily discontinued in order to evaluate the role of TC II in vitamin B 12 -mediated reactions. Within six weeks the child developed megaloblastic anemia, thrombocytopenia, leukopenia, and granulocytopenia.
C R, Scott +3 more
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Inheritance and genetic linkage of transcobalamin II
Human Genetics, 1981The genetic polymorphism of the vitamin B12 transport protein transcobalamin II (TC II) was studied in the Caucasian population and in families. There are five codominent alleles of TC II which show a Mendelian mode of inheritance. No genetic linkage of TC II was found with gene loci for ADA, GLO I, Pi, HLA, AB0 and AK1.
S Y, Yang +3 more
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Scandinavian Journal of Haematology, 1977
Insolubilized antibody to transcobalamin I was used to separate transcobalamin I and transcobalamin II. By bioautography of the extracted cobalamins it was shown that transcobalamin II bound more deoxyadenosylcobalamin than did transcobalamin I, and that methylcobalamin accounts for most of the cobalamins attached to transcobalamin I.
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Insolubilized antibody to transcobalamin I was used to separate transcobalamin I and transcobalamin II. By bioautography of the extracted cobalamins it was shown that transcobalamin II bound more deoxyadenosylcobalamin than did transcobalamin I, and that methylcobalamin accounts for most of the cobalamins attached to transcobalamin I.
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[Transcobalamins in megaloblastic anemias].
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1975Transcobalamins are proteins which carry vitamin B12 and which are normally partly unsaturated. This study of transcobalamins was carried out in 17 subjects with megaloblastic anemia (12 true cases of pernicious anemia and 5 cases of folate deficiency). Among the latter, the transcobalamins were studied in 4 cases of pernicious anemia, before and after
J, Zittoun, J, Jarret, R, Zittoun
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The Three Transcobalamins in Myeloproliferative Disorders and Acute Leukaemia
British Journal of Haematology, 1975J. Zittoun +3 more
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