Results 91 to 100 of about 2,708,442 (333)
Advanced Science, EarlyView.Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong +13 more
wiley +1 more source
Neural Regeneration Research, 2015 In the aging brain, cognitive function gradually declines and causes a progressive reduction in the structural and functional plasticity of the hippocampus. Transcranial magnetic stimulation is an emerging and novel neurological and psychiatric tool used
Zhan-chi Zhang +5 more
doaj +1 more source
Therapeutic Advances in Neurological Disorders, 2019 Acute brain ischemia causes changes in several neural networks and related cortico-subcortical excitability, both in the affected area and in the apparently spared contralateral hemisphere.
Francesco Fisicaro +6 more
semanticscholar +1 more source
Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits
Advanced Science, EarlyView.This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou +3 more
wiley +1 more source
bioRxiv, 2018 Transcranial magnetic stimulation (TMS) enables non-invasive modulation of brain activity with both clinical and research applications, but fundamental questions remain about the neural types and elements it activates and how stimulation parameters ...
A. Aberra +3 more
semanticscholar +1 more source
Review of Transcranial Magnetic Stimulation in Epilepsy.
Clinical Therapeutics, 2020 PURPOSE Despite the availability of numerous pharmacologic and nonpharmacologic antiseizure therapies, a fraction of patients with epilepsy remain refractory to current treatment options, underscoring the need for novel drugs and neuromodulatory ...
M. Tsuboyama, H. Kaye, A. Rotenberg
semanticscholar +1 more source
Advanced Science, EarlyView.This study shows that propofol modulates fear‐memory reconsolidation in mice. It works by suppressing D2 receptor‐expressing neurons within the medial prefrontal cortex and their connections to the basolateral amygdala. D2‐receptor agonists reproduce this fear‐reducing effect, offering potential non‐anesthetic therapeutic strategies for trauma‐related ...
Jie Li +11 more
wiley +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives The aim of the present study was to investigate the analgesic effects of repetitive transcranial magnetic stimulation over the primary motor cortex (M1‐rTMS) using different stimulation parameters to explore the optimal stimulus condition for treating neuropathic pain.
Nobuhiko Mori +5 more
wiley +1 more source
Non-invasive brain stimulation as a novel approach to the treatment of chronic non-specific low back pain [PDF]
, 2012 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Chronic non-specific low back pain (CNSLBP) is a widespread but poorly understood condition that places a substantial burden on the sufferer, health ...
O’Connell, Neil Edward
core +5 more sources
Neuroscience and Biobehavioral Reviews, 2019 There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug ...
H. Ekhtiari +75 more
semanticscholar +1 more source