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Visualization of Genetic Transcription
1973Transcription of structural genes by RNA polymerase to produce messenger RNAs (mRNAs) and the translation of such messengers by polyribosomes to produce proteins are intimately coupled processes in bacterial cells (1). In fact, it is possible to reconstruct coupled transcription and translation systems in vitro from separated bacterial components (2,3).
O. L. Miller, Barbara A. Hamkalo
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Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.
New England Journal of Medicine, 1997In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to the site of lesions, thereby amplifying and perpetuating the ...
P. Barnes, M. Karin
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Proceedings of the Royal Society of London. Series B. Biological Sciences, 1966
The purine and pyrimidine base sequence of DNA , permanent repository of the genetic information, must be transcribed on to ribopolynucleotides before genotype can be translated into phenotype. This transcription gives rise to three recognizably different classes of RNA molecules: (1) two ...
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The purine and pyrimidine base sequence of DNA , permanent repository of the genetic information, must be transcribed on to ribopolynucleotides before genotype can be translated into phenotype. This transcription gives rise to three recognizably different classes of RNA molecules: (1) two ...
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Transcriptional derepression as a cause of genetic diseases
Current Opinion in Genetics & Development, 2003Transcription of DNA into mRNA is a highly regulated process directed by a complex molecular machine comprising more than 100 proteins. Regulation of transcription occurs by both positive (transcriptional activation) and negative (transcriptional repression) mechanisms.
Michael R. Green +3 more
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Tissue Specificity of Genetic Transcription
1972The basic biochemical differences which exist between cells in animal tissues are reflections of characteristic patterns of proteins. The process (es) of differentiation, therefore, may be described as the process (es) whereby cells, presumably of identical genotype, develop into phenotypically distinct entities which reflect characteristic patterns of
R. B. Church, I. R. Brown
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Genetic and Epigenetic Control of RKIP Transcription
Critical Reviews in Oncogenesis, 2014Raf kinase inhibitory protein (RKIP) is known to modulate key signaling cascades and regulate normal physiological processes such as cellular proliferation, differentiation, and apoptosis. The expression of RKIP is found to be downregulated in several cancer metastases and the repressed RKIP expression can be reactivated on treatment with ...
Milad S. Bitar +6 more
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Collinearity of Transcriptional and Traditional Genetic Maps
Nature New Biology, 1972THE transcriptional mapping method1 makes possible the detection of polycistronic operons in systems which are not amenable to fine structure genetic mapping. The theory behind transcriptional mapping is that a defined interference with the travel of the genetic transcribing enzyme can be used for genetic analysis in a variety of ways.
Karen S. Webb, Michael Bleyman
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Genetic Determinants of 5–Lipoxygenase Transcription
International Archives of Allergy and Immunology, 1999<b>Background: </b>5 Lipoxygenase (5–LO) is a critical enzyme in the production of the leukotrienes. We have identified a series of mutations in the 5–LO gene that modify gene transcription. These mutations consist of addition of an Sp–1 binding motif (–GGGCGG–) or deletion of one or two Sp–1 binding motifs in the 5–LO core promoter.
Jeffrey M. Drazen, Eric S. Silverman
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Ionizing Radiation: Effect on Genetic Transcription
Science, 1964Cells of Escherichia coli grown on maltose can be induced by the addition of thiomethyl galactoside to produce β-galactosidase. If cells are irradiated shortly after induction, the transcription of the DNA ceases, and the enzyme produced by the messenger RNA is observed to reach a maximum.
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Transcription of genetic information in amphibian oocytes
Chromosoma, 1976The lampbrush chromosomes of amphibian oocytes are highly active in RNA transcription. The extent of transcription and features of the transcriptional product have been studied both cytologically and by molecular hybridization. Each lampbrush loop is considered to be a unit of transcription which generates many primary transcript molecules.
John Sommerville, David B. Malcolm
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