Results 91 to 100 of about 3,372,915 (384)
Deciphering transcriptional dynamics in vivo by counting nascent RNA molecules [PDF]
, 2013 Transcription of genes is the focus of most forms of regulation of gene expression. Even though careful biochemical experimentation has revealed the molecular mechanisms of transcription initiation for a number of different promoters in vitro, the dynamics of this process in cells is still poorly understood.
arxiv +1 more source
FEBS Letters, EarlyView.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source
Irregular transcription dynamics for rapid production of high-fidelity transcripts [PDF]
arXiv, 2012 Both genomic stability and sustenance of day-to-day life rely on efficient and accurate readout of the genetic code. Single-molecule experiments show that transcription and replication are highly stochastic and irregular processes, with the polymerases frequently pausing and even reversing direction. While such behavior is recognized as stemming from a
arxiv
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Challenges of Decoding Transcription Factor Dynamics in Terms of Gene Regulation
Cells, 2018 Technological advances are continually improving our ability to obtain more accurate views about the inner workings of biological systems. One such rapidly evolving area is single cell biology, and in particular gene expression and its regulation by ...
Erik W. Martin, Myong-Hee Sung
doaj +1 more source
Speech transcription using MED [PDF]
, 2001 MED (Media EDitor) is a program designed to facilitate the transcription of digitized soundfiles into textfiles. It was written by Hans Drexler and Daan Broeder, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Lehmann, Katrin
core
Diverse spatial expression patterns emerge from common transcription bursting kinetics [PDF]
arXiv, 2017 In early development, regulation of transcription results in precisely positioned and highly reproducible expression patterns that specify cellular identities. How transcription, a fundamentally noisy molecular process, is regulated to achieve reliable embryonic patterning remains unclear.
arxiv
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Quantification of DNA Products Using Ion-Pair Reverse Phase Liquid Chromatography [PDF]
, 2017 The transcription of DNA via RNA polymerases is a fundamental process in cellular systems. In eukaryotic cells, we observe transcription in the nucleus (via genomic DNA) as well as in the mitochondria (via mitochondrial DNA).
Bestwick, Megan, Wienkers, Henry
core +1 more source
Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]
, 2019 Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D. +3 more
core +1 more source