Results 71 to 80 of about 2,529,579 (316)

Variable structure motifs for transcription factor binding sites [PDF]

, 2010
Background: Classically, models of DNA-transcription factor binding sites (TFBSs) have been based on relatively few known instances and have treated them as sites of fixed length using position weight matrices (PWMs).
Evans, Kenneth J., Dyer, N., Nigel Dyer, Ott Sascha, Reid, J.E., Lorenz Wernisch, Sascha Ott, Ott, S., Wernisch Lorenz, John E Reid, Evans Kenneth J, Wernisch, Lorenz, Reid, J. E. (John E.), Kenneth J Evans, Dyer, Nigel, Dyer Nigel, Ott, Sascha, Reid John E   +17 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Structure of the Nipah virus polymerase phosphoprotein complex

Nature Communications
The Nipah virus (NiV), a member of the Paramyxoviridae family, is notorious for its high fatality rate in humans. The RNA polymerase machinery of NiV, comprising the large protein L and the phosphoprotein P, is essential for viral replication. This study
Ge Yang, Dong Wang, Bin Liu
doaj   +1 more source

The Fission Yeast Homeodomain Protein Yox1p Binds to MBF and Confines MBF-Dependent Cell-Cycle Transcription to G1-S via Negative Feedback [PDF]

, 2009
The regulation of the G1- to S-phase transition is critical for cell-cycle progression. This transition is driven by a transient transcriptional wave regulated by transcription factor complexes termed MBF/SBF in yeast and E2F-DP in mammals. Here we apply
Brazma Alvis, Klier, S, Codlin, S, Lackner Daniel H., Bahler, J, Alvis Brazma, Brian T Wilhelm, Robertus A M de Bruin, Sofia Aligianni, de Bruin, RAM, Daniel H Lackner, Sandra Codlin, Gabriella Rustici, Klier Steffi, Wilhelm, BT, Rustici Gabriella, Lackner, DH, Marguerat Samuel, Aligianni, S, Bähler Jürg, de Bruin, RA, Jürg Bähler, Brazma, A, Codlin Sandra, Marguerat, S, Steffi Klier, Wilhelm Brian T., Samuel Marguerat, Aligianni Sofia, de Bruin Robertus A. M., Rustici, G   +30 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation

iScience, 2018
Summary: The transcriptional co-activator p300 is essential for p53 transactivation, although its precise role remains unclear. We report that p53 activates the acetyltransferase activity of p300 through the enhancement of p300 autoacetylation ...
Stephanie Kaypee, Smitha Asoka Sahadevan, Shilpa Patil, Piya Ghosh, Neeladri Sekhar Roy, Siddhartha Roy, Tapas K. Kundu   +6 more
doaj   +1 more source

Functions of Mediator and the RNA Polymerase II C-terminal Domain in Transcription Initiation [PDF]

, 2008
RNA polymerase II (RNAPII) has been identified almost 40 years ago, but the molecular details of its regulation and fine tuning during messenger RNA (mRNA) synthesis are still far from understood. Subsequently to RNAPII six general transcription factors (
Boeing, Stefan
core  

Analyses of the archaeal transcription cycle reveal a mosaic of eukaryotic RNA polymerase II and III-like features

, 2009
Novel mechanistic properties of the archaeal transcription system that reveal similarities especially to the eukaryotic RNA polymerase II and III systems were presented in thesis.
Spitalny, Patrizia
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Whole genome sequencing of CRISPR/Cas9-engineered NF-κB reporter mice for validation and variant discovery

Scientific Data
Targeted knockout, mutations, or knock-in of genomic DNA fragments in model organisms have been used widely for functional and cell-tracking studies.
Guruswamy Mahesh, Erik W. Martin, Mohammad Aqdas, Kyu-Seon Oh, Myong-Hee Sung   +4 more
doaj   +1 more source