Results 51 to 60 of about 2,529,579 (316)

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

eLife, 2020
PPP-family phosphatases such as PP1 have little intrinsic specificity. Cofactors can target PP1 to substrates or subcellular locations, but it remains unclear how they might confer sequence-specificity on PP1.
Roman O Fedoryshchak, Magdalena Přechová, Abbey M Butler, Rebecca Lee, Nicola O'Reilly, Helen R Flynn, Ambrosius P Snijders, Noreen Eder, Sila Ultanir, Stephane Mouilleron, Richard Treisman   +10 more
doaj   +1 more source

Automatic transcription of polyphonic music exploiting temporal evolution [PDF]

, 2012
PhDAutomatic music transcription is the process of converting an audio recording into a symbolic representation using musical notation. It has numerous applications in music information retrieval, computational musicology, and the creation of ...
Emmanouil Benetos, Benetos, E
core  

transcription-factor-analysis-profacgen.jpg

, 2019
Transcription factors are proteins that bind to specific DNA sequences and regulate the transcription of genetic information from DNA to messenger RNA (mRNA). They are found in all living organisms. https://www.profacgen.com/transcription-factor-analysis.
Jerry Carter (6727871)
core   +1 more source

Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells [PDF]

, 2009
Dr1 (also known as NC2{beta}) was identified as a repressor of RNA polymerase (pol) II transcription. It was subsequently shown to inhibit pol III transcription when expressed at high levels in vitro or in yeast cells.
Theodoros Kantidakis, White, Robert J., White, R.J., Robert J. White, Kantidakis, Theodoros, Kantidakis, T.   +5 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

An R2R3 MYB transcription factor associated with regulation of the anthocyanin biosynthetic pathway in Rosaceae

, 2010
Background The control of plant anthocyanin accumulation is via transcriptional regulation of the genes encoding the biosynthetic enzymes. A key activator appears to be an R2R3 MYB transcription factor.
Wang, Kui-Lin, Kortstee, A.J., Tony K McGhie, McGhie Tony K, Hellens, R.P., Espley Richard V, Hellens Roger P, Grafton, Karryn, Espley, Richard V., Karryn Grafton, Karunairetnam, Sakuntala, Andrew C Allan, Kortstee, Anne, Roger P Hellens, Allan, A.C., Allan, Andrew C., McGhie, T.K., Richard V Espley, Kortstee Anne, Allan Andrew C, Espley, R.V., Sakuntala Karunairetnam, Karunairetnam Sakuntala, Grafton Karryn, McGhie, Tony K., Lin-Wang Kui, Bolitho, Karen, Karen Bolitho, Anne Kortstee, Bolitho Karen, Hellens, Roger P., Lin-Wang, Kui, Kui Lin-Wang   +32 more
core   +1 more source

Functional analysis of the competence transcription factor ComK of Bacillus subtilis by characterization of truncation variants [PDF]

, 2005
The competence transcription factor ComK is the master regulator of competence development in Bacillus subtilis. In the regulatory pathway, ComK is involved in different interactions: (i) protein–DNA interactions to stimulate transcription of ComK ...
Andy-Mark W. H. Thunnissen, Thunnissen, Andy-Mark W.H.,, Thunnissen, A.M.W.H.; id_orcid, Oscar P. Kuipers, Fusetti, F., Fabrizia Fusetti, Hamoen, L.W, Susanna, Kim, Kim A. Susanna, Susanna, Kim Amé,, Kuipers, Oscar P.,, Susanna, Kim A.,, Fusetti, Fabrizia,, Kuipers, O.P., Hamoen, Leendert W.,, Susanna, Kim Amé, Kuipers, O.P.; id_orcid, Thunnissen, A.M.W.H., Leendert W. Hamoen   +18 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519

Nature Communications
ERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymerase complexes at 2.73 Å and 2.48 Å resolution, revealing a unique binding ...
Dong Wang, Fan Bu, Ge Yang, Bin Liu
doaj   +1 more source

Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

eLife, 2014
Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role of nuclear architecture.
Ignacio Izeddin, Vincent Récamier, Lana Bosanac, Ibrahim I Cissé, Lydia Boudarene, Claire Dugast-Darzacq, Florence Proux, Olivier Bénichou, Raphaël Voituriez, Olivier Bensaude, Maxime Dahan, Xavier Darzacq   +11 more
doaj   +1 more source