Results 41 to 50 of about 2,793,494 (260)

ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes

Nature Communications, 2023
The function of the mitogen-activated protein kinase signaling pathway is required for the activation of immediate early genes (IEGs), including EGR1 and FOS, for cell growth and proliferation.
Heeyoun Bunch, Deukyeong Kim, Masahiro Naganuma, Reiko Nakagawa, Anh Cong, Jaehyeon Jeong, Haruhiko Ehara, Hongha Vu, Jeong Ho Chang, Matthew J. Schellenberg, Shun-ichi Sekine   +10 more
doaj   +1 more source

Feeding, Fear, and Acceptance: Caregivers’ Experiences of Nutritional Support During Childhood Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques, Mariana dos Santos Murra, Welinton Hirai, Ana Laura Balduino do Nascimento, Karla Emilia de Sá Rodrigues, Wilson Elias de Oliveira Junior   +5 more
wiley   +1 more source

Mechanistic studies of the mRNA transcription cycle

, 2006
We have now completed an atomic crystallographic model of the 12-subunit yeast RNA polymerase II in elongation mode, with DNA and RNA in the active-centre cleft, and the NTP substrate at the growing end of the RNA.
Roberts, S. G. E., Cramer, Patrick, Weinzierl, R. O. J., White, R. J., Cramer, Patrick (author)   +4 more
core   +1 more source

Structural insights into the Nipah virus nucleocapsid assembly

Communications Biology
Nipah virus (NiV), a lethal zoonotic henipavirus, poses a major public health threat. Its nucleoprotein (N) safeguards the genome by forming a nucleocapsid, which, together with the RNA-dependent RNA polymerase (L) and phosphoprotein (P), constitutes the
Ge Yang, Dmytro Kompaniiets, Dong Wang, Bin Liu   +3 more
doaj   +1 more source

Stability of the PHF10 subunit of PBAF signature module is regulated by phosphorylation: role of β-TrCP

Scientific Reports, 2017
The PBAF chromatin-remodeling complexes are multi-protein machines, regulating expression of genes involved in proliferation and differentiation. PHF10 is a subunit of the PBAF essential for its association with chromatin. Mammalian PHF10 is expressed as
Victor V. Tatarskiy, Yuriy P. Simonov, Dmitrii S. Shcherbinin, Alexander V. Brechalov, Sofia G. Georgieva, Nataliya V. Soshnikova   +5 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

SHPRH as a new player in ribosomal RNA transcription and its potential role in homeostasis of ribosomal DNA repeats

, 2017
There are hundreds of copies of rDNA repeats in mammalian chromosomes and the ratio of active, poised, or inactive rDNA is regulated in epigenetic manners.
Kim, Shinseog, Deokjae Lee, Jun Hong Park, Park, Jun Hong, Seon-gyeong Lee, Lee, Deokjae, Kyungjae Myung, Shinseog Kim, Lee, Seon-gyeong, Myung, Kyungjae   +9 more
core   +1 more source

Dia2 controls transcription by mediating assembly of the RSC complex. [PDF]

, 2011
BACKGROUND: Dia2 is an F-box protein found in the budding yeast, S. cerevisiae. Together with Skp1 and Cul1, Dia2 forms the substrate-determining part of an E3 ubiquitin ligase complex, otherwise known as the SCF.
Yu Veronica P. C. C., Veronica P. C. C. Yu, Yu, VPCC, Kessler, BM, Andress Edward J., Edelmann, MJ, Benedikt M. Kessler, Holic, R, Edelmann Mariola J., Mariola J Edelmann, Edelmann, Mariola J., Kessler Benedikt M., Mariola J. Edelmann, Yu, Veronica P. C. C., Holic, Roman, Andress, Edward J., Kessler, Benedikt M., Veronica P C C Yu, Benedikt M Kessler, Holic Roman, Edward J Andress, Roman Holic, Andress, EJ, Edward J. Andress   +23 more
core   +1 more source

Marine Antimicrobial Peptides-Based Strategies for Tackling Bacterial Biofilm and Biofouling Challenges

Molecules, 2022
An assemblage nexus of microorganisms enclosed in a composite extracellular polymeric matrix is called as a biofilm. The main factor causing biological fouling, or biofouling, is biofilms. Biofilm-mediated biofouling is a significant detrimental issue in
Anupam Patra, Jhilik Das, Nupur Rani Agrawal, Gajraj Singh Kushwaha, Mrinmoy Ghosh, Young-Ok Son   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source