Results 21 to 30 of about 2,746,686 (254)

Different functions of PHF10 isoforms – subunits of the PBAF chromatin remodeling complex

Вавиловский журнал генетики и селекции, 2019
Chromatin remodelling multiprotein complexes play an important role in regulation of gene expression in embryogenesis and in the adult organism. Mutations in the subunits of the complexes are often lethal or lead to developmental defects.
A. A. Sheynov, V. V. Tatarskiy, A. M. Azieva, S. G. Georgieva, N. V. Soshnikova   +4 more
doaj   +1 more source

Towards molecular systems biology of gene transcription and regulation [PDF]

, 2010
Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, P., Cramer, Patrick
core   +1 more source

Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy

Medicine in Drug Discovery, 2022
PE and GDM are two major metabolic diseases affecting pregnancy. Individuals suffering from GDM are at an increased risk of developing PE in later gestational stages.
Nupur Rani Agarwal, Garima Kachhawa, Bolaji Fatai Oyeyemi, Neel Sarovar Bhavesh   +3 more
doaj   +1 more source

Rho-dependent transcription termination in bacteria recycles RNA polymerases stalled at DNA lesions

Nature Communications, 2019
In bacteria, the Rho protein dislodges elongation complexes to terminate transcription, and the Mfd protein removes RNA polymerases (RNAPs) stalled at DNA lesions. Here, Jain et al.
Sriyans Jain, Richa Gupta, Ranjan Sen
doaj   +1 more source

Structural Analysis of (p)ppGpp Reveals Its Versatile Binding Pattern for Diverse Types of Target Proteins

Frontiers in Microbiology, 2020
(p)ppGpp, highly phosphorylated guanosine, are global regulatory nucleotides that modulate several biochemical events in bacterial physiology ranging from core central dogma to various metabolic pathways.
Gajraj Singh Kushwaha, Gajraj Singh Kushwaha, Anupam Patra, Neel Sarovar Bhavesh   +3 more
doaj   +1 more source

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

eLife, 2016
The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear ...
Richard Panayiotou, Francesc Miralles, Rafal Pawlowski, Jessica Diring, Helen R Flynn, Mark Skehel, Richard Treisman   +6 more
doaj   +1 more source

A novel chromatin-remodeling complex variant, dcPBAF, is involved in maintaining transcription in differentiated neurons

Frontiers in Cell and Developmental Biology, 2023
The Polybromo-associated BAF (BRG1- or BRM-associated factors) (PBAF) chromatin-remodeling complex is essential for transcription in mammalian cells.
Nataliya V. Soshnikova, Nataliya V. Soshnikova, Nataliya V. Soshnikova, Asya M. Azieva, Asya M. Azieva, Nataliya S. Klimenko, Alvina I. Khamidullina, Alexey V. Feoktistov, Alexey V. Feoktistov, Andrey A. Sheynov, Alexander V. Brechalov, Victor V. Tatarskiy, Sofia G. Georgieva   +12 more
doaj   +1 more source

The sequential phosphorylation of PHF10 subunit of the PBAF chromatin-remodeling complex determines different properties of the PHF10 isoforms

Biology Open, 2020
The mammalian PBAF subfamily of SWI/SNF chromatin remodeling complexes plays a wide role in the regulation of gene expression. PHF10 is a subunit of the signature module of PBAF, responsible for its interaction with chromatin.
Andrey A. Sheynov, Victor V. Tatarskiy, Eugene V. Tatarskiy, Elena N. Nabirochkina, Sofia G. Georgieva, Nataliya V. Soshnikova   +5 more
doaj   +1 more source

N-Terminus Plays a Critical Role for Stabilizing the Filamentous Assembly and the Antifungal Activity of Bg_9562

Microbiology Spectrum, 2022
Bg_9562, a prophage tail-like protein was earlier shown to be required for bacterial mycophagy by Burkholderia gladioli strain NGJ1. The purified protein exhibited broad-spectrum antifungal activity; however, the structural and mechanistic details vis-à ...
Pankaj Kumar Sahoo, Rahul Kumar, Aruna Rani, Sunil Kumar Yadav, Gopaljee Jha, Deepti Jain   +5 more
doaj   +1 more source

Plant Transcription Factors @ uni-potsdam.de [PDF]

, 2007
We present the Plant Transcription Factor Database (PlnTFDB), and the putative complete set of TFs in the algae _Chlamydomonas reinhardtii_, _Ostreococcus tauri_ and the vascular plants _Oryza sativa_ and _Arabidopsis ...
Slobodan Ruzicic, Ingo Dreyer, Diego Mauricio Riaño-Pachón, Bernd Mueller-Roeber   +3 more
core   +1 more source