Results 11 to 20 of about 2,529,579 (316)
Transcriptional and Post-Transcriptional Regulation of Autophagy [PDF]
Cells, 2022 Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis. It is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through multiple pathways.
Qiuqin Ma +5 more
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Boosting transcription by transcription: enhancer-associated transcripts [PDF]
Chromosome Research, 2013 Enhancers are traditionally viewed as DNA sequences located some distance from a promoter that act in cis and in an orientation-independent fashion to increase utilization of specific promoters and thereby regulate gene expression. Much progress has been made over the last decade toward understanding how these distant elements interact with target ...
Emily M, Darrow, Brian P, Chadwick
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Scientific Reports, 2021 The emergence of new primate-specific genes is an essential factor in human and primate brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation,
Alexander G. Stepchenko +6 more
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Dynamics of transcriptional and post-transcriptional regulation [PDF]
Briefings in Bioinformatics, 2020 AbstractDespite gene expression programs being notoriously complex, RNA abundance is usually assumed as a proxy for transcriptional activity. Recently developed approaches, able to disentangle transcriptional and post-transcriptional regulatory processes, have revealed a more complex scenario.
Mattia Furlan +2 more
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Cell Adhesion & Migration, 2022 The study’s aim was to investigate the S100A4-mediated mechanisms of the regulation of tumor cell proliferation and migration in the human triple-positive breast carcinoma cell line MCF-7 (TPBC) and triple-negative breast carcinoma cell line MDA-MB-231 ...
Elena A. Dukhanina +3 more
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Protocol for analysis of G2/M DNA synthesis in human cells
STAR Protocols, 2021 Summary: G2/M DNA synthesis (G-MiDS) can be observed in one in five G2/M cells in unperturbed conditions by immunofluorescence microscopy. However, little is known of the genomic sites undergoing G-MiDS.
Jianming Wang, Marco Saponaro
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Dynamic interplay between non-coding enhancer transcription and gene activity in development
Nature Communications, 2023 Non-coding transcription at the intergenic regulatory regions is a prevalent feature of metazoan genomes, but its function remains uncertain. Here the authors show that enhancer function is flexibly tunable through the modulation of hub formation via ...
Kota Hamamoto +3 more
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Falling for the dark side of transcription: Nab2 fosters RNA polymerase III transcription. [PDF]
, 2016 RNA polymerase III (RNAPIII) synthesizes diverse, small, non-coding RNAs with many important roles in the cellular metabolism. One of the open questions of RNAPIII transcription is whether and how additional factors are involved.
Reuter, LM, Sträßer, K
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Towards molecular systems biology of gene transcription and regulation [PDF]
, 2010 Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, P., Cramer, Patrick
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