Results 31 to 40 of about 4,936,819 (357)

Transcription and post-transcriptional regulation of spermatogenesis [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2010
Spermatogenesis in mammals is achieved by multiple players that pursue a common goal of generating mature spermatozoa. The developmental processes acting on male germ cells that culminate in the production of the functional spermatozoa are regulated at both the transcription and post-transcriptional levels. This review addresses recent progress towards
Anilkumar, Bettegowda, Miles F, Wilkinson   +1 more
openaire   +2 more sources

Landscape of transcription in human cells

Nature, 2012
Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations ...
S. Djebali, Carrie A. Davis, A. Merkel, A. Dobin, T. Lassmann, A. Mortazavi, Andrea Tanzer, Julien Lagarde, Wei Lin, F. Schlesinger, Chenghai Xue, G. Marinov, Jainab Khatun, B. Williams, C. Zaleski, J. Rozowsky, M. Röder, F. Kokocinski, Rehab F Abdelhamid, T. Alioto, I. Antoshechkin, Michael T. Baer, Nadav S. Bar, P. Batut, Kim Bell, I. Bell, S. Chakrabortty, Xian Chen, Jacqueline Chrast, João Curado, T. Derrien, J. Drenkow, E. Dumais, Jacqueline Dumais, R. Duttagupta, E. Falconnet, Meagan Fastuca, Katalin Fejes-Toth, Pedro G. Ferreira, S. Foissac, M. Fullwood, Hui Gao, David González, Assaf Gordon, H. Gunawardena, C. Howald, Sonali Jha, Rory Johnson, P. Kapranov, Brandon King, C. Kingswood, O. J. Luo, Eddie Park, K. Persaud, Jonathan B. Preall, Paolo Ribeca, Brian A Risk, D. Robyr, M. Sammeth, L. Schaffer, L. See, Atif Shahab, Jørgen Skancke, A. Suzuki, Hazuki Takahashi, Hagen U. Tilgner, Diane Trout, Nathalie Walters, Huaien Wang, J. Wrobel, Yanbao Yu, Xiaoan Ruan, Y. Hayashizaki, J. Harrow, M. Gerstein, T. Hubbard, A. Reymond, S. Antonarakis, G. Hannon, Morgan C. Giddings, Y. Ruan, B. Wold, Piero Carninci, R. Guigó, T. Gingeras   +84 more
semanticscholar   +1 more source

Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer

Frontiers in Immunology, 2019
Macrophages play an important role in regulating the tumor microenvironment (TME). Here we show that classical (M1) macrophage polarization reduced expression of LSD1, nuclear REST corepressor 1 (CoREST), and the zinc finger protein SNAIL.
Abel H. Y. Tan, WenJuan Tu, Robert McCuaig, Kristine Hardy, Thomasina Donovan, Sofiya Tsimbalyuk, Jade K. Forwood, Sudha Rao   +7 more
doaj   +1 more source

The Role of the Histone Variant H2A.Z in Metazoan Development

Journal of Developmental Biology, 2022
During the emergence and radiation of complex multicellular eukaryotes from unicellular ancestors, transcriptional systems evolved by becoming more complex to provide the basis for this morphological diversity.
Yasmin Dijkwel, David J. Tremethick
doaj   +1 more source

Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR [PDF]

, 2008
The Escherichia coli MelR protein is a transcription activator that autoregulates its own promoter by repressing transcription initiation. Optimal repression requires MelR binding to a site that overlaps the melR transcription start point and to upstream
Shivanthi Samarasinghe, Mohamed Samir El-Robh, David C. Grainger, Wenke Zhang, Panos Soultanas, Stephen J. W. Busby, Gralla, Choy, Rojo, Schleif, Schleif, Gallegos, Webster, Belyaeva, Wade, Webster, Webster, Michán, Kahramanoglou, Tobes, Martin, Grainger, Wade, Lodge, Williams, Grainger, Kolb, Perrin, Miller, Caswell, Hansma, Ishihama, Lee, Meares, Virnik, Wang, Zhang, Bourgerie, Semsey, Roy, Plumbridge, Kachroo   +41 more
core   +4 more sources

The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation.

Cell, 2002
We have identified a novel zinc finger-containing transcription factor, called Osterix (Osx), that is specifically expressed in all developing bones. In Osx null mice, no bone formation occurs.
K. Nakashima, Xin Zhou, G. Kunkel, Zhaoping Zhang, J. Deng, R. Behringer, Benoit de Crombrugghe   +6 more
semanticscholar   +1 more source

A global function for transcription factors in assisting RNA polymerase II termination. [PDF]

, 2017
The role of transcription factors (TFs) on nucleosome positioning, RNA polymerase recruitment, and transcription initiation has been extensively characterized.
Chanfreau, Guillaume F, Roy, Kevin
core   +1 more source

The Human Transcription Factors.

Cell, 2018
Samuel A. Lambert,1,9 Arttu Jolma,2,9 Laura F. Campitelli,1,9 Pratyush K. Das,3 Yimeng Yin,4 Mihai Albu,2 Xiaoting Chen,5 Jussi Taipale,3,4,6,* Timothy R. Hughes,1,2,* and Matthew T.
Samuel A. Lambert, A. Jolma, L. Campitelli, P. Das, Yimeng Yin, Mihai Albu, Xiaoting Chen, J. Taipale, T. Hughes, M. Weirauch   +9 more
semanticscholar   +1 more source

Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells. [PDF]

, 2018
Enhancers for embryonic stem (ES) cell-expressed genes and lineage-determining factors are characterized by conventional marks of enhancer activation in ES cells1-3, but it remains unclear whether enhancers destined to regulate cell-type-restricted ...
Destici, Eugin, Friedman, Meyer, Kim, Hong Sook, Ma, Qi, Ma, Wubin, Merkurjev, Daria, Ohgi, Kenneth, Rosenfeld, Michael G, Skowronska-Krawczyk, Dorota, Suter, Tom, Tan, Yuliang   +10 more
core   +2 more sources

The Rho-Dependent Transcription Termination Is Involved in Broad-Spectrum Antibiotic Susceptibility in Escherichia coli

Frontiers in Microbiology, 2020
One of the major ways of acquiring multidrug resistance in bacteria is via drug influx and efflux pathways. Here, we show that E. coli with compromised Rho-dependent transcription termination function has enhanced broad-spectrum antibiotic susceptibility,
Md. Hafeezunnisa, Md. Hafeezunnisa, Ranjan Sen   +2 more
doaj   +1 more source