Results 131 to 140 of about 2,206,258 (297)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Estradiol Regulation of Insulin-Like Growth Factor-I Expression in Osteoblastic Cells: Evidence for Transcriptional Control [PDF]
, 1991 Matthias Ernst, Gideon A. Rodan
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
FoxO1 promotes ovarian cancer by increasing transcription and METTL14‐mediated m6A modification of SMC4 [PDF]
Liping Tan +8 more
openalex +1 more source
Salicylates inhibit lipopolysaccharide-induced transcriptional activation of the tissue factor gene in human monocytic cells [PDF]
, 1995 Paul Oeth, Nigel Mackman
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Distinct Localization, Transcriptional Profiles, and Functionality in Early Life Tonsil Regulatory T Cells [PDF]
S Verma +11 more
openalex +1 more source