Results 141 to 150 of about 2,030,096 (261)

Cleavage of the RNA polymerase II general transcription factor TFIIB tunes transcription during stress. [PDF]

Genes Dev
Gulyas L, Lari A, Shah SB, Glaunsinger BA.   +3 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Polymerase face-off: emerging concepts in transcription-replication coordination. [PDF]

EMBO Rep
Uruci S, Lalonde M, Luijsterburg MS, Hamperl S.   +3 more
europepmc   +1 more source

Transcriptional recorder [PDF]

Nature Chemical Biology, 2018
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

RNA polymerase II transcription initiation with and without XPB translocase activity. [PDF]

Commun Biol
Zurita M, Cruz-Ruiz S, Calvario E.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Transcriptional and epigenetic regulation of autophagy: mechanisms, disease relevance and therapeutic opportunities. [PDF]

Signal Transduct Target Ther
Seo J, Park SY, Lee DC, Yoo W, Yang YR, Seo HW, Park JL, Joo JY, Park KC, Byun S.   +9 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Hypertrophic Cardiomyopathy Mutation R723G in MYH7 Enhances Its mRNA-Stability. [PDF]

Acta Physiol (Oxf)
Kowalski K, Schwarze L, Kraft T, Montag J.   +3 more
europepmc   +1 more source