Results 151 to 160 of about 2,206,258 (297)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Bidirectional promoters in Escherichia coli: regulatory rules and implications for gene expression noise. [PDF]

Nucleic Acids Res
Warman EA, Forrest D, Stringer AM, Wade JT, Grainger DC.   +4 more
europepmc   +1 more source

The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP

, 2000
Jodi L. Vogel, Thomas M. Kristie
openalex   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Basis for lineage-determining pioneer factors targeting distinct repressed chromatin states. [PDF]

Sci Adv
Katznelson A, Zhang J, Donahue G, Zaret KS.   +3 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Structures of <i>Vibrio cholerae</i> transcription complexes reveal how ToxR and TcpP recruit the RNA polymerase and activate virulence genes. [PDF]

Sci Adv
Alcaide-Jiménez A, Canals A, Baudin F, Machón C, Fàbrega-Ferrer M, Bantysh O, Pérez-Luque R, Murciano B, Mohammad AA, Rowse MJ, Ferracciolo JM, Krukonis ES, Müller CW, Coll M.   +13 more
europepmc   +1 more source

Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway

, 2006
Kurosh Ameri, Ester M. Hammond, Carsten Culmsee, Martin Kristian Raida, Dörthe M. Katschinski, Roland H. Wenger, Ernst Wagner, Roger J. Davis, T Hai, Nicholas Denko, Adrian L. Harris   +10 more
openalex   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Investigation of exJSRV LTR promoter activity based on transcription factor regulatory networks. [PDF]

Front Vet Sci
Du X, Zhang P, Duan X, Bao A, Ma X, Zhang Y, Liu S.   +6 more
europepmc   +1 more source