Results 221 to 230 of about 4,936,819 (357)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Transcription elongation can be sufficient, but is not necessary, to advance replication timing. [PDF]

EMBO Rep
Vouzas AE, Sasaki T, Rivera-Mulia JC, Turner JL, Brown AN, Alexander KE, Brueckner L, van Steensel B, Gilbert DM.   +8 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Corrigendum: The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation

Frontiers in Molecular Neuroscience, 2019
Amrutha Swaminathan, Amrutha Swaminathan, Moumita Basu, Abdelhamid Bekri, Abdelhamid Bekri, Pierre Drapeau, Pierre Drapeau, Tapas K. Kundu   +7 more
doaj   +1 more source

Structural basis of transcription-coupled RNA damage by incorporation of oxidized ribonucleotides. [PDF]

Proc Natl Acad Sci U S A
Hou P, Lee C, Chong J, Oh J, Wang D.
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

C-Terminus of Ca_v1.3 L-Type Ca²⁺ Channel Upregulates Its Own Gene Expression. [PDF]

Cells
Sleiman Y, Srivastava U, Reisqs JB, Wadgaonkar R, Qu YS, Pouliot V, Chahine M, Boutjdir M.   +7 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Regulatory T cell lineage specification by the forkhead transcription factor foxp3.

Immunity, 2005
J. Fontenot, J. P. Rasmussen, L. Williams, James L. Dooley, A. Farr, A. Rudensky   +5 more
semanticscholar   +1 more source

Reading the SINEs - functionality in noncoding RNA 'cheap genes'. [PDF]

RNA Biol
Zahavi EE, Fainzilber M.
europepmc   +1 more source