Results 111 to 120 of about 15,248,084 (403)

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Non-equilibrium dynamics of gene expression and the Jarzynski equality

, 2007
In order to express specific genes at the right time, the transcription of genes is regulated by the presence and absence of transcription factor molecules.
E. Davidson, Johannes Berg, L. Michaelis, N. van Kampen, P. T. Spellman, U. Alon   +5 more
core   +1 more source

TFBSTools: an R/bioconductor package for transcription factor binding site analysis

Bioinform., 2016
Summary: The ability to efficiently investigate transcription factor binding sites (TFBSs) genome-wide is central to computational studies of gene regulation.
Ge Tan, B. Lenhard
semanticscholar   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

In silico analysis for the presence of HARDY an Arabidopsis drought tolerance DNA binding transcription factor product in chromosome 6 of Sorghum bicolor genome [PDF]

, 2009
Expression of the Arabidopsis HARDY (hrd) DNA binding transcription factor (555 bp present on chromosome 2) has been shown to increase WUE in rice by Karaba et al 2007 (PNAS, 104:15270–15275). We conducted a detail analysis of the complete sorghum
Arun K. Shanker, B Ventateswarlu, M Maheswari, S K. Yadav   +3 more
core   +2 more sources

Quantitative transcription factor binding kinetics at the single-molecule level [PDF]

, 2008
We have investigated the binding interaction between the bacteriophage lambda repressor CI and its target DNA using total internal reflection fluorescence microscopy.
Anderson, Burz, Campbell, Chen, Dickson, Dodd, Edward C. Cox, Garcia-Parajo, Garcia-Parajo, Golding, Ido Golding, Jackson, Johnson, Johnson, Kapanidis, Kim, Kolesov, Koster, Ling Guo, López de Saro, Merabet, Meyer, N.P. Ong, Nalefski, Nelson, Nelson, Nie, Pal, Ptashne, Reichardt, Sambrook, Samiee, Sauer, Sauer, Schütz, Smith, Stayrook, Strahs, Taguchi, Tullius, Vipond, Wang, Weiss, Xie, Yufang Wang   +44 more
core   +3 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Chlorophyllase is transcriptionally regulated by CsMYB308/CsDOF3 in young leaves of tea plant

Horticultural Plant Journal, 2023
Chlorophyll contributes to tea coloration, which is an important factor in tea quality. Chlorophyll metabolism is induced by light, but the transcriptional regulation responsible for light-induced chlorophyll metabolism is largely unknown in tea leaves ...
Weimin Liu, Siyan Liu, Kaiyue Zhang, Mingwei Xie, Haiwei Sun, Xiaoqin Huang, Lixia Zhang, Min Li   +7 more
doaj  

Removing Background Co-occurrences of Transcription Factor Binding Sites Greatly Improves the Prediction of Specific Transcription Factor Cooperations

Frontiers in Genetics, 2018
Today, it is well-known that in eukaryotic cells the complex interplay of transcription factors (TFs) bound to the DNA of promoters and enhancers is the basis for precise and specific control of transcription.
Cornelia Meckbach, Edgar Wingender, Mehmet Gültas, Mehmet Gültas, Mehmet Gültas   +4 more
doaj   +1 more source

Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells. [PDF]

, 2018
Enhancers for embryonic stem (ES) cell-expressed genes and lineage-determining factors are characterized by conventional marks of enhancer activation in ES cells1-3, but it remains unclear whether enhancers destined to regulate cell-type-restricted ...
Destici, Eugin, Friedman, Meyer, Kim, Hong Sook, Ma, Qi, Ma, Wubin, Merkurjev, Daria, Ohgi, Kenneth, Rosenfeld, Michael G, Skowronska-Krawczyk, Dorota, Suter, Tom, Tan, Yuliang   +10 more
core   +2 more sources