Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro [PDF]
, 1988 The possibility of DNA-binding proteins interacting in vitro with the polymerase II transcriptional machinery was explored by using a competition assay with individual target sequences for enhancer-binding factors.
Lubon, H +5 more
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FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Modelling transcriptional regulation with a mixture of factor analyzers and variational Bayesian expectation maximization [PDF]
, 2009 Understanding the mechanisms of gene transcriptional regulation through analysis of high-throughput postgenomic data is one of the central problems of computational systems biology.
Husmeier, D. +3 more
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The transcription factor SOX4 regulates phenotypic changes in epithelial keratinocytes
, 2022 Yoshiyuki Nagaoka +8 more
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Transcriptional Regulation by Competing Transcription Factor Modules
PLoS Computational Biology, 2005 Gene regulatory networks lie at the heart of cellular computation. In these networks, intracellular and extracellular signals are integrated by transcription factors, which control the expression of transcription units by binding to cis-regulatory regions on the DNA.
Rutger Hermsen +2 more
openaire +6 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Functional and cell-specific regulation of the Brn-3b transcription factor by microRNAs [PDF]
, 2010 Post-transcriptional gene regulation is a very powerful and evolutionary conserved mechanism which allows cells to finely modulate gene expression by acting at the level of their mRNAs.
Calissano, M.
core
Deregulation of sucrose-controlled translation of a bZIP-type transcription factor results in sucrose accumulation in leaves [PDF]
, 2011 Sucrose is known to repress the translation of Arabidopsis thaliana AtbZIP11 transcript which encodes a protein belonging to the group of S (S - stands for small) basic region-leucine zipper (bZIP)-type transcription factor.
Sunil Kumar Thalor +31 more
core +1 more source
Review of: "Hypoxia-inducible factor 1α induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/β-catenin transcriptional cofactor BCL9" [PDF]
, 2022 Hiroaki Nakamura
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