Results 141 to 150 of about 1,606,785 (217)

Wheat GT-1-like Transcription Factor Boosts Cutin Biosynthesis. [PDF]

Biomolecules
Shan Y, Yusup M, Li H, Zhi P, Wang X, Liu J, Chang C.   +6 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A transcription factor by any other name - function beyond DNA binding and transactivation. [PDF]

EMBO Rep
Schuh CM, Brickman JM.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A Red-Blooded Transcription Factor

PLoS Biology, 2004
doaj  

An expanded codebook of human transcription factor DNA-binding specificity. [PDF]

Nature
Jolma A, Laverty KU, Fathi A, Yang AWH, Yellan I, Vorontsov IE, Gralak AJ, Kribelbauer-Swietek JF, Inukai S, Razavi R, Albu M, Brechalov A, Patel ZM, Nozdrin V, Meshcheryakov G, Buyan A, Kozin I, Abramov S, Boytsov A, Codebook Consortium, Morris Q, Weirauch MT, Fornes O, Makeev VJ, Grau J, Grosse I, Bucher P, Deplancke B, Kulakovskiy IV, Hughes TR.   +29 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

MITF Is an Essential and Functionally Multifaceted Transcription Factor in Cutaneous Melanoma. [PDF]

Cancers (Basel)
Ondrušová L, Kreisingerová K, Vachtenheim J.   +2 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Motif-Cluster: Motif driven prioritization of transcription factor binding clusters. [PDF]

PLoS Comput Biol
Zhou M, Yao Q.
europepmc   +1 more source