Results 161 to 170 of about 1,824,501 (365)

Structure of the Complete RNA Polymerase II Elongation Complex and its Interaction with the Elongation Factor TFIIS [PDF]

, 2005
This thesis describes crystal structures of complete, 12-subunit yeast RNA polymerase II (Pol II) in complex with a synthetic transcription bubble and product RNA, with an NTP substrate analogue, and in complex with the transcription elongation factor ...
Kettenberger, Hubert
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Tomato heat stress transcription factor HsfB1 represents a novel type of general transcription coactivator with a histone-like motif interacting with HAC1/CBP [PDF]

, 2005
In contrast to the class A heat stress transcription factors (Hsfs) of plants, a considerable number of Hsfs assigned to classes B and C have no evident function as transcription activators on their own.
Bharti, Kapil
core  

TF Profiler: a transcription factor inference method that broadly measures transcription factor activity and identifies mechanistically distinct networks

Genome Biology
TF Profiler is a method of inferring transcription factor (TF) regulatory activity, i.e., when a TF is present and actively participating in the regulation of transcription, directly from nascent sequencing assays such as PRO-seq and GRO-seq.
Taylor Jones, Rutendo F. Sigauke, Lynn Sanford, Dylan J. Taatjes, Mary A. Allen, Robin D. Dowell   +5 more
doaj   +1 more source

The binding site for the liver-specific transcription factor Tf-LF1 and the TATA box of the human transferrin gene promoter are the only elements necessary to direct liver-specific transcriptionin vitro

, 1990
Daniel Mendelzon, F. Boissier, Mario M. Zakin   +2 more
openalex   +2 more sources

Regulation and function of the tissue-specific transcription factor HNF1 alpha (LFB1) during Xenopus development [PDF]

, 1996
Heike Weber, Elke Pogge von Strandmann, Beatrix Holewa, Sigrid Bartkowski, Dirk Zapp, Christiane Zoidl, Gerhart U. Ryffel   +6 more
openalex   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Role of Transcription Factor PU.I in the Activity of the Intronic Enhancer of the Eosinophil-Derived Neurotoxin (RNS2) Gene [PDF]

, 1998
Thamar B. van Dijk, Eric Caldenhoven, Jan A. M. Raaijmakers, Jan‐Willem J. Lammers, Leo Koenderman, Rolf P. de Groot   +5 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Apoptotic pathway is induced with SSPYY by activation of 68kD cells membrane receptor with an increase in cytoplasmic ERK-1 and an increase in nuclear Elk-1 transcription factor to induce pancreatic cancer cell death [PDF]

, 2003
Adriana Deganutti, Carson D. Liu
openalex   +1 more source