Transcription networks in liver development and acute liver failure
Liver Research, 2023 Acute liver failure (ALF) is a medical emergency due to massive hepatocyte loss. In such a harsh condition, maintaining transcriptional regulation in the remaining hepatocytes while activating similar transcription factor networks in liver progenitor ...
Rilu Feng, Roman Liebe, Hong-Lei Weng
doaj
Specific interaction between a transcription factor and the upstream element of the adenovirus-2 major late promoter. [PDF]
, 1985 Neil G. Miyamoto +3 more
openalex +1 more source
Most Probable Evolution Trajectories in a Genetic Regulatory System Excited by Stable Lévy Noise [PDF]
arXiv, 2018 We study the most probable trajectories of the concentration evolution for the transcription factor activator in a genetic regulation system, with non-Gaussian stable L\'evy noise in the synthesis reaction rate taking into account. We calculate the most probable trajectory by spatially maximizing the probability density of the system path, i.e., the ...
arxiv
Combinatorial transcription factors
Current Opinion in Genetics & Development, 1998 Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern assembly of these complexes.
openaire +3 more sources
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source
Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription. [PDF]
, 1989 Trevor Dale +6 more
openalex +1 more source
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo. [PDF]
, 1988 Jan Wijnholds, J.N.J. Philipsen, G. Ab
openalex +1 more source
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Escherichia coli transcription termination factor rho has a two-domain structure in its activated form. [PDF]
, 1985 David G. Bear +6 more
openalex +1 more source