Results 321 to 330 of about 1,824,501 (365)
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Eukaryotic transcription factors
Current Opinion in Structural Biology, 1998The structural characterization of eukaryotic transcription factors that interact with DNA has advanced on two fronts in the past two years. New complexes of transcription factors bound to TATA-box DNA include the TFIIA-TBP-DNA complex as well as human and archaeal TBP-DNA and TFIIB-TBP-DNA complexes, respectively.
Tan S, Richmond TJ
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Molecular Biology, 2012
Transcription factor RUNX1 is one of the key regulatory proteins in vertebrates. It controls hematopoiesis and angiogenesis. It is indispensable during embryogenesis for the emergence of sites of definitive hematopoiesis and later in mature organisms for bone marrow blood stem cells differentiation.
E N, Markova +3 more
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Transcription factor RUNX1 is one of the key regulatory proteins in vertebrates. It controls hematopoiesis and angiogenesis. It is indispensable during embryogenesis for the emergence of sites of definitive hematopoiesis and later in mature organisms for bone marrow blood stem cells differentiation.
E N, Markova +3 more
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Cytokines and transcription factors
Cytokine, 1990Transcriptional induction is mediated by transcription factors, which influence gene expression by interacting with specific elements in their regulatory regions. Here we discuss transcription factors involved in the regulation of cytokines and their receptors (interleukin-2, interleukin-2 receptor alpha chain, and interferon-beta), as well as ...
K, Muegge, S K, Durum
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Transcription factors in hematopoiesis
Current Opinion in Genetics & Development, 1999The advent of gene targeting in the mouse has led to rapid advances in the identification of factors controlling gene expression that are essential for normal hematopoietic development. Recent work has also uncovered roles for some of these factors in leukemogenesis and in the global regulation of chromatin structure.
I, Engel, C, Murre
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Transcription factors on the move
Trends in Genetics, 2001We think of transcription factors as being confined to the cell where they are transcribed, but recent work shows they are able to move from cell to cell in plants. Plant cells are thought to communicate through membrane-lined channels called plasmodesmata.
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2006
POU domain transcription factor proteins are critical regulators of many developmental processes during embryogenesis, are prominent in the neural system where they are identified as BRN transcription factors, and can be reactivated during malignant transformation of cancerous tissue. This family of genes is characterized by a common 150-160 amino acid
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POU domain transcription factor proteins are critical regulators of many developmental processes during embryogenesis, are prominent in the neural system where they are identified as BRN transcription factors, and can be reactivated during malignant transformation of cancerous tissue. This family of genes is characterized by a common 150-160 amino acid
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Transcription factors: An overview
The International Journal of Biochemistry & Cell Biology, 1997This special issue of the International Journal of Biochemistry and Cell Biology contains a series of review articles and original papers dealing with the topic of transcription factors. The purpose of this introductory article is to provide an overview of these factors, their mechanism of action, their regulation and the manner in which alterations in
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Trends in Plant Science, 2010
WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and
Rushton, P. +3 more
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WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and
Rushton, P. +3 more
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Transcription factors in disease
Current Opinion in Genetics & Development, 1996Mutations affecting several predominantly tissue-specific transcriptional regulators have recently been associated with disease phenotypes. Although the mutational spectrum is variable, many of the reported cases involve clear loss-of-function mutations-such as Waardenburg syndrome type 1, aniridia and Rubinstein-Taybi syndrome-suggesting that the ...
D, Engelkamp, V, van Heyningen
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Eukaryotic transcription factors
Current Opinion in Structural Biology, 2002Recently determined high-resolution structures of eukaryotic transcription factors have illuminated the enzymatic mechanism underlying transcription. Progress has been made in characterising protein-protein interactions between negative cofactors and general transcription factors, and between transrepression domains and corepressors.
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