Results 341 to 350 of about 15,248,084 (403)
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Best Practice & Research Clinical Rheumatology, 2001
The regulation of gene expression by transcription factors is fundamental to the phenotype of all cells. The activated phenotype of cells engaged in inflammatory processes is characterized by induced expression of a diverse set of genes, including cytokines, enzymes and cell adhesion molecules.
M L, Handel, L, Girgis
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The regulation of gene expression by transcription factors is fundamental to the phenotype of all cells. The activated phenotype of cells engaged in inflammatory processes is characterized by induced expression of a diverse set of genes, including cytokines, enzymes and cell adhesion molecules.
M L, Handel, L, Girgis
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2022
Transcription factors (TFs) are a large family of regulatory proteins that can increase or decrease the transcription of a particular gene from deoxyribonucleic acid into the corresponding ribonucleic acid. The modular structure of TFs and the presence of distinct interacting domains determine the ability of these factors to associate with each other ...
Caramori G. +7 more
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Transcription factors (TFs) are a large family of regulatory proteins that can increase or decrease the transcription of a particular gene from deoxyribonucleic acid into the corresponding ribonucleic acid. The modular structure of TFs and the presence of distinct interacting domains determine the ability of these factors to associate with each other ...
Caramori G. +7 more
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Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.
New England Journal of Medicine, 1997In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to the site of lesions, thereby amplifying and perpetuating the ...
P. Barnes, M. Karin
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Molecular Biology, 2012
Transcription factor RUNX1 is one of the key regulatory proteins in vertebrates. It controls hematopoiesis and angiogenesis. It is indispensable during embryogenesis for the emergence of sites of definitive hematopoiesis and later in mature organisms for bone marrow blood stem cells differentiation.
Sergey V. Razin +3 more
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Transcription factor RUNX1 is one of the key regulatory proteins in vertebrates. It controls hematopoiesis and angiogenesis. It is indispensable during embryogenesis for the emergence of sites of definitive hematopoiesis and later in mature organisms for bone marrow blood stem cells differentiation.
Sergey V. Razin +3 more
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Transcription factors in autoimmunity
Current Opinion in Immunology, 2003The identification of two transcription factors that, when mutated, are responsible for severe autoimmune disease in humans is leading to a better understanding of the fundamental processes involved in T-cell tolerance. Both AIRE and FOXP3, identified initially via their association with genetically manipulated mice, are critically involved in ...
Steven F. Ziegler, Fred Ramsdell
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Transcription factor complexes
Current Opinion in Structural Biology, 2002Considerable progress has been made during the past year on structural studies of the eukaryotic and bacterial transcription factors that control RNA polymerase function via the formation of multiprotein complexes on promoter DNA. Recently determined structures include negative cofactor 2 recognizing a preformed TATA-box-binding protein-DNA binary ...
Stephen K. Burley, Katsuhiko Kamada
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Transcription factors on the move
Current Opinion in Plant Biology, 2012Mobile transcription factors play essential roles in plant development including the control of cell identity and tissue patterning, as well as organ initiation and the induction of major developmental switches. Within the past few years, the molecules and cellular structures that regulate the movement of these signals have emerged.
Kimberly L. Gallagher, Shuang Wu
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Transcription factors: An overview
The International Journal of Biochemistry & Cell Biology, 1997This special issue of the International Journal of Biochemistry and Cell Biology contains a series of review articles and original papers dealing with the topic of transcription factors. The purpose of this introductory article is to provide an overview of these factors, their mechanism of action, their regulation and the manner in which alterations in
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Transcription Factors and Hypopituitarism
Trends in Endocrinology & Metabolism, 1999Several homeodomain factors are found in the developing anterior pituitary lobe. The production of these developmental transcription factors has distinct temporal and spatial patterns. By interacting with each other, as well as with other extrinsic and intrinsic signals, they control cell determination and specification.
Sally Radovick +2 more
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2002
Publisher Summary Asthma and chronic obstructive pulmonary disease (COPD) are characterized by an increased expression of the components of the inflammatory cascade. Inflammation is the central feature of both the diseases as both involve the recruitment and activation of inflammatory cells and changes in the structural cells of the lung.
Ian M. Adcock, Gaetano Caramori
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Publisher Summary Asthma and chronic obstructive pulmonary disease (COPD) are characterized by an increased expression of the components of the inflammatory cascade. Inflammation is the central feature of both the diseases as both involve the recruitment and activation of inflammatory cells and changes in the structural cells of the lung.
Ian M. Adcock, Gaetano Caramori
openaire +3 more sources