Results 41 to 50 of about 990,927 (122)

Development of a new treatment for osteoporotic vertebral fractures using adipose-derived stem cell spheroids

Bone & Joint Research
Aims: Osteoporotic vertebral fractures substantially contribute to disability and often require surgical intervention. However, some challenges, such as implant failure and suboptimal bone regeneration, limit current treatments.
Yuta Sawada, Shinji Takahashi, Kumi Orita, Akito Yabu, Masayoshi Iwamae, Yuki Okamura, Yuto Kobayashi, Hiroshi Taniwaki, Hiroaki Nakamura, Hidetomi Terai   +9 more
doaj   +1 more source

Expression of xCT and activity of system xc− are regulated by NRF2 in human breast cancer cells in response to oxidative stress

Redox Biology, 2015
Cancer cells adapt to high levels of oxidative stress in order to survive and proliferate by activating key transcription factors. One such master regulator, the redox sensitive transcription factor NF E2 Related Factor 2 (NRF2), controls the expression ...
Eric Habib, Katja Linher-Melville, Han-Xin Lin, Gurmit Singh   +3 more
doaj   +1 more source

Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis

Current Research in Food Science
Resveratrol (RES), a natural polyphenolic compound, has shown promise in enhancing skeletal muscle regeneration and metabolic function. This study aims to explore the impact of RES on muscle regeneration after injury through the regulation of antioxidant
Xiaoli Qin, Wenjing Niu, Kai Zhao, Yawen Luo, Wenfang Wang, Yang He, Fuyu Yang, Binghai Cao, Min Du, Huawei Su   +9 more
doaj   +1 more source

Protein Post-Translational Modifications in Plant Abiotic Stress Responses

Plants
Protein post-translational modifications (PTMs), as an important biological process of plants responding to environmental stimuli, can regulate the chemical decoration and properties of translated proteins by altering amino acid side chains or protein ...
Gengmi Li, Baohua Feng, Qian-Hao Zhu, Kaifeng Jiang, Tao Zhang   +4 more
doaj   +1 more source

Thyroid Hormone-Induced Cytosol-to-Nuclear Translocation of Rat Liver Nrf2 Is Dependent on Kupffer Cell Functioning

The Scientific World Journal, 2012
L-3,3′,5-triiodothyronine (T3) administration upregulates nuclear factor-E2-related factor 2 (Nrf2) in rat liver, which is redox-sensitive transcription factor mediating cytoprotection.
Luis A. Videla, Pamela Cornejo, Pamela Romanque, Catherine Santibáñez, Iván Castillo, Romina Vargas   +5 more
doaj   +1 more source

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 inhibition alleviates intestinal impairment induced by chronic heat stress in finisher broilers

Poultry Science
: Heat stress (HS) in poultry has deleterious effects on intestinal development and barrier function, along with inflammatory outbursts. In the present study, chronic HS reduced body weight of broilers and activated mucosa-associated lymphoid tissue ...
Huaiyong Zhang, Herinda Pertiwi, Maryam Majdeddin, Joris Michiels   +3 more
doaj   +1 more source

Differential Gene Expression and Protein–Protein Interaction Networks in Bovine Leukemia Virus Infected Cattle: An RNA-Seq Study

Pathogens
Introduction: Bovine leukemia virus is a single-stranded RNA virus that targets B cell CD5+ lymphocytes in cattle. Only a tiny percentage of individuals develop malignant lymphoproliferative disorders, while most remain healthy carriers or experience ...
Ana S. González-Méndez, Mohammad Mehdi Akbarin, Fernando Cerón-Téllez, Gabriel Eduardo Acevedo-Jiménez, Cecilia Rodríguez-Murillo, Víctor David González-Fernández, Lucero de María Ávila-De la Vega, Marisela Leal-Hernández, Hugo Ramírez Álvarez   +8 more
doaj   +1 more source

Human Bone Marrow Stromal Cells: A Reliable, Challenging Tool for In Vitro Osteogenesis and Bone Tissue Engineering Approaches

Stem Cells International, 2016
Adult human bone marrow stromal cells (hBMSC) are important for many scientific purposes because of their multipotency, availability, and relatively easy handling. They are frequently used to study osteogenesis in vitro. Most commonly, hBMSC are isolated
Ute Hempel, Katrin Müller, Carolin Preissler, Carolin Noack, Sabine Boxberger, Peter Dieter, Martin Bornhäuser, Manja Wobus   +7 more
doaj   +1 more source

The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection

Cell Reports
Summary: Activation of endosomal Toll-like receptor (TLR) 7, TLR9, and TLR11/12 is a key event in the resistance against the parasite Toxoplasma gondii.
Milton Pereira, Theresa Ramalho, Warrison A. Andrade, Danielle F. Durso, Maria C. Souza, Katherine A. Fitzgerald, Douglas T. Golenbock, Neal Silverman, Ricardo T. Gazzinelli   +8 more
doaj   +1 more source

Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression

Molecular Biomedicine
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, underscoring the need for deeper insights into its molecular mechanisms.
Lin Zhang, Jingyi Xiang, Yali Feng, Gufang Shen, Xu Huang, Tianshu Fang, Yunjia Zhu, Hong Ren, Chungang Liu   +8 more
doaj   +1 more source