Results 31 to 40 of about 990,927 (122)

Molecular docking of polyether ether ketone and nano-hydroxyapatite as biomaterial candidates for orthodontic mini-implant fabrication. [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2022
Context: Modified polyether ether ketone (PEEK) by adding nano-hydroxyapatite (HA) material on its fixture for mini-implant fabrication may increase resistance force through osseointegration.
I Gusti Aju Wahju Ardani, Alexander Patera Nugraha, Monika Nilam Suryani, Ryan Hafidz Putra Pamungkas, Devani Githa Vitamamy, Rizky Alif Susanto, Riyanarto Sarno, Aziz Fajar, Viol Dhea Kharisma, Albertus Putera Nugraha, Tengku Natasha Eleena binti Tengku Ahmad Noor   +10 more
doaj  

The developmental Wnt signaling pathway effector β-catenin/TCF mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism.

PLoS Biology, 2019
The bipartite transcription factor β-catenin (β-cat)/T cell factor (TCF), formed by free β-cat and a given TCF family member, serves as the effector of the developmental Wnt signaling cascade.
Lili Tian, Weijuan Shao, Wilfred Ip, Zhuolun Song, Yasaman Badakhshi, Tianru Jin   +5 more
doaj   +1 more source

Multidimensional Predictors of Tirzepatide Efficacy: Clinical, Genetic, and Molecular Biomarkers for Glycemic, Weight, and Organ Protection

Pharmaceuticals
Tirzepatide, a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, demonstrates robust efficacy in glycemic control and weight reduction.
Min Hyeok Shin, Jin Woo Jeong, Se Eun Ha, Rajan Singh, Moon Young Lee, Seungil Ro, Tae Yang Yu   +6 more
doaj   +1 more source

Genome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer

Frontiers in Cell and Developmental Biology
IntroductionProgrammed death-ligand 1 (PD-L1) plays essential roles in the negative regulation of anti-tumor immunity. However, the regulatory mechanisms of PD-L1 expression need further exploration.
Wenxuan Fu, Wenxuan Fu, Xiaomeng Chang, Xiaomeng Chang, Xiaomeng Chang, Kun Ye, Kun Ye, Zige Zheng, Zige Zheng, Qianyi Lai, Qianyi Lai, Minyang Ge, Minyang Ge, Yan Shi, Yan Shi, Yan Shi   +15 more
doaj   +1 more source

Flowering stage- and cultivar-specific regulation of cannabinoid biosynthesis in hemp: An integrated transcriptomics and metabolomic analyses

Industrial Crops and Products
Cannabis sativa (hemp), produces cannabidiol (CBD), a major cannabinoid. Cultivars with stable cannabinoid levels enable efficient extraction and have substantial industrial value.
Prakash Basnet, Sevin Lee, Beom-Soon Choi, Nam-Il Park, Kyoungcheul Park, Sang Hoon Kim, Grace Lachica, Taejung Kim, Dong-Young Woo, Jungyeob Ham, Taeyoung Um, Ik-Young Choi   +11 more
doaj   +1 more source

Marine Microorganism-Derived Macrolactins Inhibit Inflammatory Mediator Effects in LPS-Induced Macrophage and Microglial Cells by Regulating BACH1 and HO-1/Nrf2 Signals through Inhibition of TLR4 Activation

Molecules, 2020
Recently, many natural products with unique structure and promising pharmacological potential have been reported from marine-derived microorganisms. The macrolactin A (MA), 15-epi-dihydromacrolactin F (DMF) and macrolactin F (MF) were obtained from the ...
Eun-Nam Kim, Ming Gao, Hyukjae Choi, Gil-Saeng Jeong   +3 more
doaj   +1 more source

Glucocorticoid receptor occupancy of key bovine alphaherpesvirus 1 (BoHV-1) promoters correlates with chromatin remodeling during reactivation from latency

Journal of Virology
Bovine alphaherpesvirus 1 (BoHV-1) continues to be a significant bovine pathogen. Acute infections culminate in lifelong latent infections in sensory neurons of trigeminal ganglia (TG) and the central nervous system.
Jeffery B. Ostler, Clinton Jones
doaj   +1 more source

The Importance of the Prenyl Group in the Activities of Osthole in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro

International Journal of Endocrinology, 2014
Osteoporosis treatment always aimed at keeping the balance of bone formation and bone resorption. Recently, prenyl group in natural products has been proposed as an active group to enhance the osteogenesis process.
Yuan-Kun Zhai, Ya-Lei Pan, Yin-Bo Niu, Chen-Rui Li, Xiang-Long Wu, Wu-Tu Fan, Ting-Li Lu, Qi-Bing Mei, Cory J. Xian   +8 more
doaj   +1 more source

Endoplasmic Reticulum Stress and Neurodegeneration in Experimental Cerebral Malaria

Neurosignals, 2012
Experimental cerebral malaria (ECM) resulting from Plasmodium berghei ANKA (PbA) infection in mice results in neuronal cell death. However, the precise mechanisms leading to neuronal cell death in ECM have not been fully elucidated. In the present study,
Sripada Santosh Anand, Phanithi Prakash Babu   +1 more
doaj   +1 more source

Effects of exogenous brassinosteroids on REVEILLE 7-like gene expression in winter wheat under low temperature stress

Guangxi Zhiwu
‘Dongnong Dongmai No.1'(Dn1)is the first hardy cold-resistant variety that can be planted in a large area in the frigid regions, and the regreening rate is over 85%.
CHEN Yushu1, ZHANG Junbao1, WANG Xuesong1, SHAO Qingyi1, YANG Sen1, CAO Jia'ang1, LIU Lijie1,2*
doaj   +1 more source