Results 21 to 30 of about 990,927 (122)

Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance

Frontiers in Molecular Neuroscience, 2018
Morphine tolerance remains an intractable problem, which hinders its prolonged use in clinical practice. Endoplasmic reticulum (ER) stress has been proved to play a fundamental role in the pathogenesis of Alzheimer’s disease, diabetes, atherosclerosis ...
Daiqiang Liu, Yaqun Zhou, Yawen Peng, Peng Su, Zheng Li, Qiaoqiao Xu, Ye Tu, Xuebi Tian, Hui Yang, Zhen Wu, Wei Mei, Feng Gao   +11 more
doaj   +1 more source

Multiple ShKT domain-containing MUL-1 proteins act as redox-responsive modulators of oxidative stress signaling in C. elegans

Molecules and Cells
: Organismal survival depends on coordinated responses to oxidative stress and DNA damage. Using Caenorhabditis elegans, we investigate mul-1, a robust transcriptional target of ionizing radiation and reactive oxygen species.
Emilio Carranza-García, Abe Gayle Santos, Kyoung-Hye Yoon, Anton Gartner   +3 more
doaj   +1 more source

SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability. [PDF]

PLoS ONE, 2011
Differentiated embryo-chondrocyte expressed gene 1 (DEC1, also known as sharp2, stra13, or BHLHB2) is a mammalian basic helix-loop-helix protein that is involved in many aspects of gene regulation through acting as a transcription factor. Changes in DEC1
Yongde Hong, Xinrong Xing, Shujing Li, Hailian Bi, Chunhua Yang, Feng Zhao, Ying Liu, Xiang Ao, Alan K Chang, Huijian Wu   +9 more
doaj   +1 more source

Glucagon-Like Peptide-2 Analogue ZP1849 Augments Colonic Anastomotic Wound Healing

Gastroenterology Research and Practice, 2020
Background. The enteroendocrine hormone glucagon-like peptide- (GLP-) 2 is a potent trophic factor in the gastrointestinal tract. The GLP-2 receptor (GLP-2R) is expressed in the stroma of the large bowel wall, which is the major therapeutic target area ...
Marie Kjaer, Wayne Russell, Peter Schjerling, Elena Cottarelli, Kennet N. Christjansen, Ditte M. G. Olsen, Peter-Martin Krarup, Lene Jessen, Mark Berner-Hansen, Lars N. Jorgensen, Magnus S. Ågren   +10 more
doaj   +1 more source

Isolation and Identification of Prepubertal Buffalo () Spermatogonial Stem Cells [PDF]

Asian-Australasian Journal of Animal Sciences, 2016
Isolation and culture of spermatogonial stem cells (SSCs) are attractive for production of genetic modified offspring. In the present study, buffalo spermatogonial stem-like cells were isolated, cultured and expression pattern of different germ cell ...
Wanyou Feng, Shibei Chen, Dagiang Do, Qinyou Liu, Yanfei Deng, Xiaocan Lei, Chan Luo, Ben Huang, Deshun Shi   +8 more
doaj   +1 more source

Aciculatin inhibits granulocyte colony-stimulating factor production by human interleukin 1β-stimulated fibroblast-like synoviocytes. [PDF]

PLoS ONE, 2012
The expression of granulocyte colony-stimulating factor (G-CSF), the major regulator of neutrophil maturation, by human fibroblast-like synoviocytes (FLS) can be stimulated by the inflammatory cytokine interleukin-1β (IL-1β). G-CSF is known to contribute
Kao-Shang Shih, Jyh-Horng Wang, Yi-Wen Wu, Che-Ming Teng, Chien-Chih Chen, Chia-Ron Yang   +5 more
doaj   +1 more source

Insulin-Like Growth Factor Binding Proteins in Kidney Disease

Frontiers in Pharmacology, 2021
The seven members of the insulin-like growth factor (IGF) binding protein family (IGFBPs) were initially considered to be the regulatory proteins of IGFs in the blood circulation, mainly as the subsequent reserve for bidirectional regulation of IGF ...
Shuqiang Wang, Shuqiang Wang, Kun Chi, Di Wu, Quan Hong   +4 more
doaj   +1 more source

Multi-locus genome wide association study uncovers genetics of fresh seed dormancy in groundnut

BMC Plant Biology
Pre-harvest sprouting (PHS) in groundnut leads to substantial yield losses and reduced seed quality, resulting in reduced market value of groundnuts. Breeding cultivars with 14–21 days of fresh seed dormancy (FSD) holds promise for precisely mitigating ...
Deekshitha Bomireddy, Vinay Sharma, Sunil S. Gangurde, D. Khaja Mohinuddin, Rakesh Kumar, Ramachandran Senthil, Kuldeep Singh, Mangala Reddisekhar, Sandip K. Bera, Manish K. Pandey   +9 more
doaj   +1 more source

MAVS disruption impairs downstream signaling and results in higher virus replication levels of salmonid alphavirus subtype 3 but not infectious pancreatic necrosis virus in vitro

Frontiers in Immunology
The mitochondrial anti-viral signaling (MAVS) protein is an intermediary adaptor protein of retinoic acid-inducible gene-1 (RIG-I) like receptor (RLR) signaling, which activates the transcription factor interferon (IFN) regulatory factor 3 (IRF3) and NF ...
Cheng Xu, Amr A. A. Gamil, Xiaolin Wang, Hetron Mweemba Munang’andu, Øystein Evensen   +4 more
doaj   +1 more source

Genetic dissection of monosaccharides contents in rice whole grain using genome‐wide association study

The Plant Genome, 2023
The simplest form of carbohydrates are monosaccharides which are the building blocks for the synthesis of polymers or complex carbohydrates. Monosaccharide contents of 197 rice accessions were quantified by HPAEC‐PAD in rice (Oryza sativa L.) whole grain
Rahele Panahabadi, Asadollah Ahmadikhah, Naser Farrokhi   +2 more
doaj   +1 more source