Results 11 to 20 of about 990,927 (122)

Physiological and Transcriptomic Responses to Nitrogen Deficiency in Neolamarckia cadamba

open access: yesFrontiers in Plant Science, 2021
Nitrogen (N) is one of the abundant and essential elements for plant growth and development, and N deficiency (ND) affects plants at both physiological and transcriptomic levels.
Lu Lu   +16 more
doaj   +1 more source

Curcumin Improves Epithelial Barrier Integrity of Caco-2 Monolayers by Inhibiting Endoplasmic Reticulum Stress and Subsequent Apoptosis

open access: yesGastroenterology Research and Practice, 2021
Curcumin is a natural polyphenol and is supposed to possess antioxidant, anti-inflammatory, anticancer, and antiapoptotic properties. Although some studies have reported the therapeutic effects of curcumin on ulcerative colitis (UC), the specific ...
Xinxin Zhou   +5 more
doaj   +1 more source

Genetic variants of cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 and transcription factor 7-like 2 are not associated with polycystic ovary syndrome in Chinese women

open access: yesGynecological Endocrinology, 2009
Polycystic ovary syndrome (PCOS) is a common disorder in women that shares many genetic features with type 2 diabetes mellitus. Novel risk loci for type 2 diabetes, single nucleotide polymorphism (SNP) rs7756992 in cyclin-dependent kinase 5 (CDK5) regulatory subunit associated protein 1-like 1 (CDKAL1), rs290487 and rs11196218 in transcription factor 7-
Xiangdong, Liu   +5 more
openaire   +2 more sources

Regulation of Cell Proliferation and Nrf2-Mediated Antioxidant Defense: Conservation of Keap1 Cysteines and Nrf2 Binding Site in the Context of the Evolution of KLHL Family

open access: yesLife, 2023
Keap1 (Kelch-like ECH-associated protein 1) is one of the major negative regulators of the transcription factor Nrf2 (nuclear factor erythroid-2-related factor 2), which induces the expression of numerous proteins defending the cell against different ...
Gregory A. Shilovsky, Daria V. Dibrova
doaj   +1 more source

Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult Mice. [PDF]

open access: yesPLoS ONE, 2016
The transcription factor NF-E2-related factor 2 (Nrf2) induces cytoprotective genes, but has also been linked to the regulation of hepatic energy metabolism. In order to assess the pharmacological potential of hepatic Nrf2 activation in metabolic disease,
Sebastian Brachs   +10 more
doaj   +1 more source

QTL Mapping by SLAF-seq and Expression Analysis of Candidate Genes for Aphid Resistance in Cucumber

open access: yesFrontiers in Plant Science, 2016
Cucumber, a very important vegetable crop worldwide, is easily damaged by pests. Aphid is one of the most serious cucumber pests and frequently cause severe damage to commercially produced crops.
Danna Liang   +6 more
doaj   +1 more source

Microarray Analysis of the Molecular Mechanism Involved in Parkinson’s Disease

open access: yesParkinson's Disease, 2018
Purpose. This study aimed to investigate the underlying molecular mechanisms of Parkinson’s disease (PD) by bioinformatics. Methods. Using the microarray dataset GSE72267 from the Gene Expression Omnibus database, which included 40 blood samples from PD ...
Cheng Tan, Xiaoyang Liu, Jiajun Chen
doaj   +1 more source

Gene expression programs during callus development in tissue culture of two Eucalyptus species

open access: yesBMC Plant Biology, 2022
Background Eucalyptus is a highly diverse genus of the Myrtaceae family and widely planted in the world for timber and pulp production. Tissue culture induced callus has become a common tool for Eucalyptus breeding, however, our knowledge about the genes
Ye Zhang   +8 more
doaj   +1 more source

NEFA Promotes Autophagosome Formation through Modulating PERK Signaling Pathway in Bovine Hepatocytes

open access: yesAnimals, 2021
During the perinatal period, the abnormally high plasma non-esterified fatty acids (NEFA) concentration caused by the negative energy balance (NEB) can impose a significant metabolic stress on the liver of dairy cows. Endoplasmic reticulum (ER) stress is
Yan Huang   +11 more
doaj   +1 more source

1,25-hydroxyvitamin D3 decreases endoplasmic reticulum stress-induced inflammatory response in mammary epithelial cells.

open access: yesPLoS ONE, 2020
Recent studies indicated that intramammary administration of active vitamin D3 hormone (1,25D3) inhibits the inflammatory process associated with mastitis.
Gaiping Wen, Klaus Eder, Robert Ringseis
doaj   +1 more source

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