Results 91 to 100 of about 38,959 (207)

Knowledge Management and Innovation in Human Resources: Strategic Competencies for Digital Transformation

Knowledge and Process Management, EarlyView.
ABSTRACT This study examines how knowledge management (KM) structures the dynamics of challenges and competencies associated with digital transformation within the human resources (HR) function in the context of Industry 4.0. Adopting a qualitative, exploratory, and prospective research design, the study combines the Delphi technique with ...
Celso Machado Júnior, Vilma Aparecida Caseiro, Elza Fátima Rosa Veloso, Edson Keyso de Miranda Kubo, Raquel da Silva Pereira, Daielly Melina Nassif Mantovani, Roberto Bazanini, Cristiane Jaciara Furlaneto, Marcia Eleane Braghini Deus Deu   +8 more
wiley   +1 more source

Exometabolomics Reveals Metabolic Modulation Induced by Chia Oil Supplementation in Adipose Tissue Explants From Obese Mice

Lipids, EarlyView.
The experimental design and the exometabolomic findings obtained by 1H‐NMR analysis of conditioned media from subcutaneous (SAT) and epididymal adipose tissue (EAT) explants of control and obese mice supplemented with chia oil (1.5% (w/w)). Following 8 weeks of control or high‐fat diet and 5 weeks of chia oil supplementation, SAT and EAT explants were ...
Gilson Costa dos Santos Jr, Agatha Assis‐Ferreira, Gabrielly Muniz‐Cassuce, Tatiana El Bacha, Christina Barja‐Fidalgo, Simone Vargas da Silva   +5 more
wiley   +1 more source

Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3

MedComm
Periodontitis is a chronic periodontal inflammatory disease caused by periodontal pathogens commonly seen in adults. Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a potential drug ...
Wenhua Kuang, Ruishen Zhuge, Ping Song, Letai Yi, Shujie Zhang, Ying Zhang, Yin Kwan Wong, Ruixing Chen, Junzhe Zhang, Yuanbo Wang, Dandan Liu, Zipeng Gong, Peili Wang, Xiangying Ouyang, Jigang Wang   +14 more
doaj   +1 more source

Regenerative Injection Laryngoplasty With Scaffold‐Forming Oligomer and Autologous Motor Endplate‐Expressing Cells: A 6‐Month Porcine Study

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Injection laryngoplasty is a standard‐of‐care intervention for unilateral vocal fold paralysis (UVFP), offering minimally invasive medialization with limited durability. We evaluated a regenerative injectable approach integrating an immunotolerant scaffold‐forming collagen (Oligomer) with autologous motor‐endplate expressing (MEE ...
Gabriel G. Sobczak, Rachel A. Morrison, Lujuan Zhang, Patrick R. Finnegan, Benjamin Johnson, Eric Dong, Bailey Egan, Aditya Bhatt, Sherry L. Voytik‐Harbin, Stacey Halum   +9 more
wiley   +1 more source

Functional validation of driver mutation‐specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity

The Journal of Pathology, EarlyView.
Abstract Uveal melanoma (UM) is a deadly ocular malignancy with well‐described genetic alterations that predict disease outcome. However, our current understanding of the biological underpinnings of high‐risk uveal melanoma progression remains relatively limited. Using RNA expression profiles from 250 patients with UM, we identified 12 novel biomarkers
QCC van den Bosch, RM Verdijk, H Fadlelseed, TPP van den Bosch, S Owens, S Kennedy, E Kilic, E Brosens   +7 more
wiley   +1 more source

Optical genome mapping enhanced by refined variant interpretation in pediatric acute lymphoblastic leukemia

The Journal of Pathology, EarlyView.
Abstract Reliable detection of structural variants (SVs) and copy number variations (CNVs) is crucial in the contemporary diagnostics of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). However, limitations of commonly used conventional and molecular cytogenetic methods may hinder the accurate genetic characterization of patients.
Anna Bekő, Borbála Péterffy, Alex Hughes, Janka Sára Jakab, Irén Haltrich, Kristóf Balázs Árvai, Gábor Bedics, Katalin Csonka, Gergő Papp, Dóra Kapczár, Bettina Aranka Bohusné Barta, Lajos László Hegyi, Gábor Szalóki, Gábor Barna, András Matolcsy, Bálint Egyed, Zsuzsanna Hevessy, Anne Benard‐Slagter, Sander Palit, Suvi Savola, Csaba Bödör, Donát Alpár   +21 more
wiley   +1 more source

A perspective on autophagy and transcription factor EB in Alcohol-Associated Alzheimer's disease. [PDF]

Biochem Pharmacol, 2023
Zhang C, Chen H, Rodriguez Y, Ma X, Swerdlow RH, Zhang J, Ding WX.   +6 more
europepmc   +1 more source

Universal and Lineage‐Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo, Jimin Pei, Jing Zhang, Qian Cong, Nick V. Grishin, R. Dustin Schaeffer   +5 more
wiley   +1 more source

Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer's Disease and Parkinson's Disease. [PDF]

Aging Dis, 2023
Yang J, Zhang W, Zhang S, Iyaswamy A, Sun J, Wang J, Yang C.   +6 more
europepmc   +1 more source

A Triangulenum‐Based Biosensor Platform for Mapping Kinase Activity in T Cells

Small, EarlyView.
Novel peptide biosensors based on long‐lifetime triangulenium dyes are developed for the real‐time, non‐invasive mapping of Akt1 and Src kinase activities in living cells. Utilizing FLIM microscopy, these highly specific, biocompatible probes overcome cellular autofluorescence.
Carmen Salto‐Giron, Angélica Martín‐Priego, Francisco Fueyo‐González, María Mar Quesada‐Moreno, Federico Movilla, Antonio Reinoso, Laura Espinar‐Barranco, Rafael Salto, Amparo Navarro, Miguel Fribourg, Angel Orte, Juan A. González‐Vera   +11 more
wiley   +1 more source