Results 1 to 10 of about 15,357 (224)

Targeted dephosphorylation of TFEB promotes its nuclear translocation [PDF]

iScience
Summary: Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localized to the cytoplasm ...
Jin-Feng Zhao, Natalia Shpiro, Gajanan Sathe, Abigail Brewer, Thomas J. Macartney, Nicola T. Wood, Florentina Negoita, Kei Sakamoto, Gopal P. Sapkota   +8 more
doaj   +2 more sources

TFEB: A Emerging Regulator in Lipid Homeostasis for Atherosclerosis [PDF]

Frontiers in Physiology, 2021
Atherosclerosis, predominantly characterized by the disturbance of lipid homeostasis, has become the main causation of various cardiovascular diseases. Therefore, there is an urgent requirement to explore efficacious targets that act as lipid modulators ...
Manman Li, Zitong Wang, Pengyu Wang, Hong Li, Liming Yang   +4 more
doaj   +3 more sources

mTOR-dependent TFEB activation and TFEB overexpression enhance autophagy-lysosome pathway and ameliorate Alzheimer's disease-like pathology in diabetic encephalopathy

Cell Communication and Signaling, 2023
Background Diabetic encephalopathy (DE) is a complication of type 2 diabetes mellitus (T2DM) that features Alzheimer's disease (AD)-like pathology, which can be degraded by the autophagy-lysosome pathway (ALP).
Lizhen Cheng, Yixin Chen, Donghao Guo, Yuan Zhong, Wei Li, Yijia Lin, Ya Miao   +6 more
doaj   +2 more sources

Downregulation of transcription factor EB inhibits the growth and metastasis of colorectal carcinomas

European Journal of Inflammation, 2018
To determine the roles of transcription factor EB (TFEB) in colorectal cancer (CRC), we collected samples of tumor tissues and normal tissues from 40 patients with CRC.
Jin-Zhe Chang, Shu-Dong Chen, Hui Zheng, Hua-Ping Zhang   +3 more
doaj   +1 more source

Extracellular Acidification Impairs Macrophage Lipophagy Through ASIC1/RIP1 Pathway

Shengwu huaxue yu shengwu wuli jinzhan
ObjectiveOur recent study has demonstrated that extracellular acidification promotes lipid accumulation in macrophages via the activation of acid sensing ion channel 1 (ASIC1), but the underlying mechanism remains unclear.
LIU Juan, OU Xiang, LIU Qing, GUO Miao, NING Zi-Ping, GU Hong-Feng, TANG Ya-Ling   +6 more
doaj   +1 more source

Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson’s disease

Frontiers in Neuroscience, 2023
Mutations in the GBA1 gene are the single most frequent genetic risk factor for Parkinson’s disease (PD). Neurodegenerative changes in GBA1-associated PD have been linked to the defective lysosomal clearance of autophagic substrates and aggregate-prone ...
Fahad Mubariz, Afsoon Saadin, Nicholas Lingenfelter, Chinmoy Sarkar, Aditi Banerjee, Marta M. Lipinski, Marta M. Lipinski, Ola Awad   +7 more
doaj   +1 more source

Cadmium targeting transcription factor EB to inhibit autophagy-lysosome function contributes to acute kidney injury

Journal of Advanced Research
Introduction: Environmental and occupational exposure to cadmium (Cd) has been shown to cause acute kidney injury (AKI). Previous studies have demonstrated that autophagy inhibition and lysosomal dysfunction are important mechanisms of Cd-induced AKI ...
Peng-Fei Dong, Tian-Bin Liu, Kai Chen, Dan Li, Yue Li, Cai-Yu Lian, Zhen-Yong Wang, Lin Wang   +7 more
doaj   +1 more source

Salmonella actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner

Microbiology Spectrum
The transcription factor TFEB drives the expression of lysosomal, autophagic, and immune-responsive genes in response to LPS and phagocytosis. Interestingly, compounds that promote TFEB activity enhance bactericidal activity, while intracellular ...
Subothan Inpanathan, Erika Ospina-Escobar, Vanessa Cruz Li, Zainab Adamji, Tracy Lackraj, Youn Hee Cho, Natasha Porco, Christopher H. Choy, Joseph B. McPhee, Roberto J. Botelho   +9 more
doaj   +1 more source

Atg8ylation as a general membrane stress and remodeling response

Cell Stress, 2021
The yeast Atg8 protein and its paralogs in mammals, mammalian Atg8s (mAtg8s), have been primarily appreciated for their participation in autophagy. However, lipidated mAtg8s, including the most frequently used autophagosomal membrane marker LC3B, are ...
Suresh Kumar, Jingyue Jia1, Vojo Deretic
doaj   +1 more source

Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress

Frontiers in Physiology, 2019
Macroautophagy (referred to as autophagy hereafter) plays an important role in the quality control of cellular proteins and organelles. Transcription Factor EB (TFEB) globally activates the expression of genes in the autophagic-lysosomal pathway (ALP) to
Bo Pan, Megan T. Lewno, Penglong Wu, Penglong Wu, Xuejun Wang   +4 more
doaj   +1 more source