Results 41 to 50 of about 15,357 (224)
Cells, 2020 Silicosis is an occupational lung disease characterized by persistent inflammation and irreversible fibrosis. Crystalline silica (CS) particles are mainly phagocytized by alveolar macrophages (AMs), which trigger apoptosis, inflammation, and pulmonary ...
Xiu He +8 more
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Cells, 2020 Peroxisome proliferator-activated receptor α (PPARα) shows promising potential to enhance host defenses against Mycobacterium tuberculosis infection.
Yi Sak Kim +12 more
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EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation.
PLoS Biology, 2023 The stress-responsive transcription factor EB (TFEB) is a master controller of lysosomal biogenesis and autophagy and plays a major role in several cancer-associated diseases.
Marcella Cesana +11 more
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EGR1 positively modulates TFEB transcription.
, 2023 (A) Schematic representation of the filtering strategy to identify regulators of TFEB transcription. TFs were selected according to several criteria: (i) the number of predicted binding sites at the level of the identified CREs (Bumscore >3) and their ...
Davide Cacchiarelli (75128) +11 more
core +1 more source
Transcription factor EB regulates cardiovascular homeostasis
EBioMedicine, 2021 Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator ...
Haocheng Lu +4 more
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TFEB overexpression promotes cell migration.
, 2023 (A) Representative images of wound healing assay acquired at 24 hours from the removal of silicone insert. HeLa-FLCN KO expressing low (+TFEB low) or high (+TFEB high) levels of TFEB, along with control cells (CTRL) were employed for the migration assay.
Davide Cacchiarelli (75128) +11 more
core +1 more source
Regulation of TFEB and V‐ATPases by mTORC1 [PDF]
The EMBO Journal, 2011 Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is an important, highly conserved, regulator of cell growth. Ancient among the signals that regulate mTORC1 are nutrients. Amino acids direct mTORC1 to the surface of the late endosome/lysosome, where mTORC1 becomes receptive to other inputs.
Peña-Llopis, Samuel +8 more
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TFEB transcriptional responses reveal negative feedback by BHLHE40 and BHLHE41 [PDF]
, 2020 Transcription factor EB (TFEB) activates lysosomal biogenesis genes in response to environmental cues. Given implications of impaired TFEB signaling and lysosomal dysfunction in metabolic, neurological, and infectious diseases, we aim to systematically ...
Ferder, Ianina +32 more
core +1 more source
TFEB is a master regulator of tumor-associated macrophages in breast cancer
Journal for ImmunoTherapy of Cancer, 2020 Background Tumor-associated macrophages (TAMs) play key roles in the development of many malignant solid tumors including breast cancer. They are educated in the tumor microenvironment (TME) to promote tumor growth, metastasis, and therapy resistance ...
Qing Liu +9 more
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TFEB and TFE3 drive kidney cystogenesis and tumorigenesis
EMBO Molecular Medicine, 2023 Abstract Birt‐Hogg‐Dubé (BHD) syndrome is an inherited familial cancer syndrome characterized by the development of cutaneous lesions, pulmonary cysts, renal tumors and cysts and caused by loss‐of‐function pathogenic variants in the gene encoding the tumor‐suppressor protein folliculin (FLCN).
Chiara Di Malta +22 more
openaire +5 more sources