Results 61 to 70 of about 15,357 (224)
Role of TFEB in Huntington’s Disease
BiologyHuntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by an expansion of the CAG trinucleotide repeat in exon 1 of the huntingtin (HTT) gene. This expansion leads to a polyglutamine (polyQ) tract at the N-terminal end of HTT, which reduces the solubility of the protein and promotes its accumulation.
Javier Ojalvo-Pacheco +4 more
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TFEB differentially targets various forms of pTau.
, 2020 A-B. Western blot and quantification showing significant reduction in various forms of tau via WT– 0N3R, (0N3R) T231D/S235D, (0N4R) P301L, and WT– 0N4R with the addition of constitutive overexpression of TFEB activity. Results indicated most forms of tau
Praveen Chander (157613) +4 more
core +1 more source
The architectural structure of human TFEB locus.
, 2023 (A) (Left) Boxplot showing the gene expression distribution of TFEB across different tissues. The average nTPM value for each tissue has been recovered from Human Protein Atlas (proteinatlas.org).
Davide Cacchiarelli (75128) +11 more
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Immunohistochemical expression of GPNMB in TFEB-rearranged and TFEB-amplified renal cell carcinomas
Virchows ArchivAbstract TFEB -altered renal cell carcinomas (RCCs) display a wide range of morphological features and variable immunohistochemical profiles, often overlapping with other RCC subtypes. This variability poses significant diagnostic challenges.
Kristyna Pivovarcikova +22 more
openaire +2 more sources
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex [PDF]
, 2023 : The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy1. The phosphorylation of TFEB by the mechanistic target of rapamycin complex 1 (mTORC1)2-5 is unique in its mTORC1 substrate recruitment mechanism, which is ...
Ballabio, Andrea +8 more
core +1 more source
Advanced Science, EarlyView.This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan +12 more
wiley +1 more source
Role of TFEB in regulation of the podocyte actin cytoskeleton
Archives of Biochemistry and Biophysics, 2023 Podocyte injury is linked to the pathogenesis and progression of renal disease. The Transcription Factor EB (TFEB), a master regulator of the autophagy and lysosomal pathways, has been found to exert cell- and tissue-specific biological function. To explore TFEB function and underlying mechanisms in podocytes, a total of 4645 differentially expressed ...
Cuili Li +13 more
openaire +2 more sources
ROLE OF TRANSCRIPTION FACTOR EB (TFEB) IN CARDIAC HEALTH AND DISEASE
, 2020 Cardiomyopathy is prevalent and the leading cause of mortality among obese and diabetic patients. Abnormalities in cardiac energy metabolism trigger myocyte dysfunction that precedes the onset of cardiomyopathy.
Trivedi, Purvi
core
Advanced Science, EarlyView.IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia +8 more
wiley +1 more source
TFEB nuclear translocation after trehalose treatment.
, 2023 A. HT and NPC1 mutant fibroblasts immunolabeled with TFEB and DAPI showing nuclear translocation of TFEB after 24hrs of SSM + 100mM trehalose. Scale bar: (A) 40 μm. (TIF)
Lindsay Walsh (17512400) +9 more
core +1 more source