Results 81 to 90 of about 15,357 (224)
Transition metals activate TFEB in overexpressing cells [PDF]
Biochemical Journal, 2015 Transition metal toxicity is an important factor in the pathogenesis of numerous human disorders, including neurodegenerative diseases. Lysosomes have emerged as important factors in transition metal toxicity because they handle transition metals via endocytosis, autophagy, absorption from the cytoplasm and exocytosis.
Peña, Karina A., Kiselyov, Kirill
openaire +2 more sources
Analysis of HuDe fibroblasts over-expressing TFEB.
, 2014 A, Immunoblotting of cells transfected with TFEB. Extracts from cells transfected with TFEB or empty vector as control were incubated with an anti-TFEB antibody. As internal control, an anti-βactin antibody was used. B, Reporter activity of HEXA promoter
Carla Emiliani (184188) +9 more
core +1 more source
Transcription factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress
Life Science AllianceTFEB promotes TNBC self-renewal and protects TNBC stem cells against metabolic stress via unfolded protein response and autophagy, revealing vulnerabilities that could be therapeutically exploited.
Milad Soleimani +8 more
doaj +1 more source
TFEB-mTORC1 feedback loop in metabolism and cancer [PDF]
Cell Stress, 2017 no abstract ...
Di Malta, Chiara, Ballabio, Andrea
openaire +4 more sources
Advanced Science, EarlyView.Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo +5 more
wiley +1 more source
eLife, 2018 The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner.
Owen A Brady +5 more
doaj +1 more source
Carbon Anodes for Low‐Temperature Nonaqueous Alkali Metal‐Ion Batteries
EcoEnergy, EarlyView.This review summarizes recent progress in carbon anodes for low‐temperature nonaqueous alkali‐metal ion batteries. Fundamental thermodynamic and kinetic limitations are examined, alongside a systematic discussion of graphite, hard carbon, and emerging carbon architectures.
Zhichun Miao +11 more
wiley +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
, 2020 Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) and its analogues are potent anti-cancer agents through their ability to target lysosomes.
Richardson, DR, Krishan, S, Sahni, S
core +1 more source
iMetaMed, EarlyView.This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu +7 more
wiley +1 more source