Results 101 to 110 of about 15,357 (224)
Cell Proliferation, EarlyView.This study identifies a link between periodontitis and CRC progression mediated by carnosine‐enriched circulating EVs. These EVs target the intestine and elevate tumour cell intracellular pH (pHi), which rescues lysosomal function. This process drives a transition from dysfunctional lysosomes to functional ones, promoting a high malignancy phenotype in
Ruoyi Wu +15 more
wiley +1 more source
, 2019 As a master regulator of the macroautophagy/autophagy-lysosomal pathway, TFEB (transcription factor EB) plays a prominent role in regulating neurodegenerative diseases and cancer.
Yang Xu (178421) +5 more
core +1 more source
mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells
Disease Models & Mechanisms, 2019 Bi-allelic GBA1 mutations cause Gaucher's disease (GD), the most common lysosomal storage disorder. Neuronopathic manifestations in GD include neurodegeneration, which can be severe and rapidly progressive.
Robert A. Brown +8 more
doaj +1 more source
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source
An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense [PDF]
, 2016 SummaryThe mechanisms that tightly control the transcription of host defense genes have not been fully elucidated. We previously identified TFEB as a transcription factor important for host defense, but the mechanisms that regulate TFEB during infection ...
Visvikis, Orane +7 more
core +1 more source
Histopathology, EarlyView.This study supports the need for ancillary testing to diagnose ESC‐RCC versus TFEB‐amplified RCC, as neither morphology nor immunohistochemistry is sufficiently specific to distinguish these entities. The underlying molecular drivers in each tumour are pathogenic TSC1 or TSC2 gene variants in ESC‐RCC and TFEB gene amplification in TFEB‐amplified RCC ...
Hayley Zullow +3 more
wiley +1 more source
Post-translational regulation of TFEB/3 activity [PDF]
The ability of cells to sense and adapt to changes in their environment is critical for their survival. Cancer cells acquire the ability to promote cell growth and proliferation independently of growth factors, whilst retaining the ability to sense and ...
Andrews, Sarah
core +1 more source
TFEB nuclear translocation after trehalose treatment in WT COSCs.
, 2023 A. WT P10 + 4DIV COSCs immunolabeled with TFEB, CALB, and DAPI showing nuclear TFEB immunoreactivity in CALB+ PCs (PC DAPI+ nuclei are circled by dashed lines) after trehalose treatment. B. Quantitative analysis of CALB+ PCs with nuclear translocation of
Lindsay Walsh (17512400) +9 more
core +1 more source
Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases
Periodontology 2000, EarlyView.Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva +2 more
wiley +1 more source
iScienceSummary: Transcription factor EB (TFEB) is a key transcription factor that orchestrates the cellular response to stress. Dysregulation of TFEB is associated with a range of human diseases, and understanding the regulatory mechanisms of TFEB is crucial ...
Juan A. Garcia-Sanchez +14 more
doaj +1 more source