Results 111 to 120 of about 15,357 (224)

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

SEARCH FOR ARE REGULATORY SEQUENCES IN GENES of MASTER REGULATORS OF autophagy and LYSOSOMAL BIOGENESIS TFEB AND TFE3

Сибирский научный медицинский журнал, 2019
Transcription factors TFEB and TFE3 are the master regulators of lysosomal biogenesis and autophagy and control most of the protein genes involved in the formation of lysosomes by interacting with the promoters of these genes containing the regulatory ...
A. V. Chechushkov, E. B. Menshchikova
doaj   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease

BioEssays, Volume 48, Issue 10, October 2026.
Recent human genetic studies highlight the critical role of microglial pathways in Alzheimer's disease, with risk loci enriched in microglia‐specific genes such as SPI1 and MEF2C. Dysregulation of these transcription factors contributes to disease pathogenesis.
Byungwook Kim, Selena S. Wang, Justin R. Kim, Jungsu Kim   +3 more
wiley   +1 more source

TFEB Expression Profiling in Renal Cell Carcinomas: Clinicopathologic Correlations

, 2019
TFEB is overexpressed in TFEB-rearranged renal cell carcinomas as well as in renal tumors with amplifications of TFEB at 6p21.1. As recent literature suggests that renal tumors with 6p21.1 amplification behave more aggressively than those with ...
Sirintrapun, Sahussapont J, Salazar, Paulo A, Reuter, Victor E, Williamson, Sean R, Ladanyi, Marc, Jungbluth, Achim A, Mcfarlane, Tiffany, Mehra, Rohit, Arcila, Maria E, Hes, Ondrej, Argani, Pedram, Antonescu, Cristina R, Sanchez, Alejandro, Gupta, Sounak, Tickoo, Satish K, Gopalan, Anuradha, Skala, Stephanie L, Hakimi, Abraham A, Fine, Samson W, Chen, Ying-Bei, Al-Ahmadie, Hikmat A   +20 more
core   +1 more source

Elevated TFEB expression with limited activation in peripheral blood mononuclear cells reflects altered lysosomal enzyme dynamics in Parkinson's disease

Neurobiology of Disease
Background: Lysosomal dysfunction is recognized as a key pathological feature of Parkinson's disease (PD); however, its peripheral signatures remain unclear.
Yasuaki Mizutani, Kazuki Nawashiro, Souta Ito, Tsuyoshi Nakai, Reiko Ohdake, Sayuri Shima, Akihiro Ueda, Mizuki Ito, Tatsuro Mutoh, Hirohisa Watanabe   +9 more
doaj   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex

Nature Communications
Tuberous Sclerosis Complex (TSC) is caused by TSC1 or TSC2 mutations, leading to hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) and lesions  in multiple organs including lung (lymphangioleiomyomatosis) and kidney (angiomyolipoma ...
Nicola Alesi, Damir Khabibullin, Dean M. Rosenthal, Elie W. Akl, Pieter M. Cory, Michel Alchoueiry, Samer Salem, Melissa Daou, William F. Gibbons, Jennifer A. Chen, Long Zhang, Harilaos Filippakis, Laura Graciotti, Caterina Miceli, Jlenia Monfregola, Claudia Vilardo, Manrico Morroni, Chiara Di Malta, Gennaro Napolitano, Andrea Ballabio, Elizabeth P. Henske   +20 more
doaj   +1 more source

Wogonin, a bioactive flavonoid from Scutellaria baicalensis, alleviates alcoholic pancreatitis via AMPK-mediated TFEB activation

Journal of Advanced Research
Introduction: Transcription factor EB (TFEB) deficiency contributes to insufficient autophagic degradation, resulting in zymogen granule (ZG) accumulation and subsequent premature activation, which underlies the pathogenesis of alcoholic pancreatitis (AP)
Zhen Qin, Xiaohong Sun, Jingmin Zeng, Guorong Li, Haixia Wang, Shujun Chen, Shiyun Tan, Lin An, Caiyan Wang, Liming Wang, Jinping Wang, Xiaowen Ma, Zhongxiang Zhao, Xiaojuan Chao, Zhongqiu Liu, Shaogui Wang   +15 more
doaj   +1 more source

Give me a SINE: how Selective Inhibitors of Nuclear Export modulate autophagy and aging

Molecular & Cellular Oncology, 2018
Autophagy is a cellular recycling process leading to lysosomal degradation of damaged macromolecules, which can protect cells against aging. The transcription factor EB (TFEB), a major transcriptional regulator of genes involved in autophagy and ...
A.V. Kumar, T.G. Thakurta, M.J. Silvestrini, J.R. Johnson, R.A. Reenan, L.R. Lapierre   +5 more
doaj   +1 more source