Results 131 to 140 of about 15,357 (224)
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.SIRT1, an NAD+‐dependent deacetylase, supports cognitive resilience by coordinating neuroprotection, synaptic plasticity, autophagy–lysosomal proteostasis, and mitochondrial energy homeostasis. Reduced or dysregulated SIRT1 is associated with protein aggregation, neuroinflammation, mitochondrial dysfunction, synaptic loss, and cognitive decline in ...
Jiabin Duan +6 more
wiley +1 more source
Drug Design, Development and Therapy, 2020 Lijuan Gao,1,2,* Xiaoqiong Li,1,2,* Shi Meng,1,2,* Tengyun Ma,1,2 Lihong Wan,3,* Shijun Xu1,2,* 1College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, People’s Republic of China; 2Institute of Meterial ...
Gao L, Li X, Meng S, Ma T, Wan L, Xu S
doaj
TFEB overexpression results in reduced accumulation of α-syn aggregates.
, 2015 a) Fluorescence microscopy analyses of H4/α-syn-GFP cells transduced to express TFEB-3xFLAG or S142A TFEB-3xFLAG. Images of α-syn-GFP fluorescence (green, column 1) and aggregates, detected using the ProteoStat dye (red, column 2), were merged (column 3)
Tommy Hancock (705918) +3 more
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Brain-XActivation of transcription factor EB (TFEB), a key regulator of autophagy induction and lysosomal biogenesis, is considered a promising therapeutic strategy for treating the currently incurable Parkinson's disease (PD).
Sisi Wang +10 more
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The Character of Transcription Factor EB(TFEB) Mechanism in Glioblastoma
, 2016 Oligomerization property of TFEB was already revealed by structural analysis. Nowadays researchers generally study about the effect of TFEB. The research was based on the cytosolic localization of TFEB.
성기준
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Tem activates the endogenous TRPML1-TFEB pathway.
, 2019 (A) Tem (10 μM, 9 h) induced TFEB (green) nuclear translocation in WT but not ML1−/− fibroblasts. TFEB nuclear translocation was inhibited by coapplication of ML-SI3 (10 μM). Nuclei were labelled with DAPI (red, pseudo-color). Scale bar = 10 μm.
Rong Shao (202747) +18 more
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Regulation of
Physiological ReportsAbstractWhile cellular proteins exist in a dynamic state maintained by the balance of synthesis and degradation, there is a paucity of information on these processes in placental trophoblasts, including within cytotrophoblasts which differentiate into multi‐nucleate syncytiotrophoblasts. TFEB, a transcription factor with a myriad of cellular activities,
A. Mathew +5 more
openaire +3 more sources
The 5'ends of TFEB in melanoma
, 2014 Leysikornið er eins konar endurvinnslustöð frumunnar en það gegnir lykilhlutverki í viðbrögðum við næringarskorti og hreinsar upp gölluð prótein eða gömul og úr sér gengin frumulíffæri með sjálfsáti.
Katrín Möller 1989-
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Advanced ScienceSmurf1 mediates lysosomal biogenesis upon endomembrane damage by interacting with lysosomal injury sensor Gal3 and phosphatase CaN to form Gal3‐CaN‐Smurf1 complex, which is critical for TFEB dephosphorylation.
Qin Xia +10 more
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TFEB in MNC1 is predominantly cytosolic.
C57BL/6 mice were infected with by aerosol with ~100 Mtb H37Rv-mCherry. At 28 dpi, lung cells were harvested for analysis. (A) RNA-seq data show that MNC1 express lower levels of Tfeb mRNA than do AM (28 dpi).
Joel D. Ernst (7392614) +7 more
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