Transcription factor EB as a key molecular factor in human health and its implication in diseases [PDF]
SAGE Open Medicine, 2023 Transcription factor EB, as a component of the microphthalmia family of transcription factors, has been demonstrated to be a key controller of autophagy–lysosomal biogenesis.
Alemu Gebrie
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Transcription factor EB regulates cardiovascular homeostasis [PDF]
EBioMedicine, 2021 Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator ...
Haocheng Lu +4 more
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Transcription factor EB (TFEB) improves ventricular remodeling after myocardial infarction by inhibiting Wnt/β-catenin signaling pathway [PDF]
PeerJ, 2023 Background Adverse left ventricular remodeling after myocardial infarction (MI) compromises cardiac function and increases heart failure risk. Until now, comprehension of the role transcription factor EB (TFEB) plays after MI is limited.
Cong Liu +12 more
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The Oncogene Transcription Factor EB Regulates Vascular Functions [PDF]
Frontiers in Physiology, 2021 Transcription factor EB (TFEB) represents an emerging player in vascular biology. It belongs to the bHLH-leucine zipper transcription factor microphthalmia family, which includes microphthalmia-associated transcription factor, transcription factor E3 and
Gabriella Doronzo +5 more
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Transcription factor EB, a promising therapeutic target in cardiovascular disease [PDF]
PeerJCardiovascular disease (CVD) remains the major cause of morbidity and mortality around the world. Transcription factor EB (TFEB) is a master regulator of lysosome biogenesis and autophagy.
Xin Yan +6 more
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The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2021 Transcription factor EB (TFEB) is a member of the microphthalmia-associated transcription factor/transcription factor E (MiTF/TFE) family and critically involved in the maintenance of structural integrity and functional balance of multiple cells. In this
Sheng-yu Zhu +9 more
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Age-related driving mechanisms of retinal diseases and neuroprotection by transcription factor EB-targeted therapy [PDF]
Neural Regeneration ResearchRetinal aging has been recognized as a significant risk factor for various retinal disorders, including diabetic retinopathy, age-related macular degeneration, and glaucoma, following a growing understanding of the molecular underpinnings of their ...
Samuel Abokyi, Dennis Yan-yin Tse
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Role of myeloid cell transcription factor EB in alcohol-induced liver injury in mice [PDF]
Liver ResearchBackground and aims: Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide, with no currently effective treatment. ALD is caused by excessive lipid buildup, which eventually triggers inflammation and
Sha Neisha Williams +4 more
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Transcription factor EB regulates phosphatidylinositol-3-phosphate levels that control lysosome positioning in the bladder cancer model [PDF]
Communications Biology, 2023 In aggressive bladder cancer cells, the transcription factor EB is activated, leading to increased endosomal phosphatidylinositol-3-phosphate levels and lysosome dispersion to the cells’ periphery.
Pallavi Mathur +7 more
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Transcription factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress [PDF]
Life Science AllianceTFEB promotes TNBC self-renewal and protects TNBC stem cells against metabolic stress via unfolded protein response and autophagy, revealing vulnerabilities that could be therapeutically exploited.
Milad Soleimani +8 more
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