Results 11 to 20 of about 38,959 (207)

TFEBexplorer: An integrated tool to study genes regulated by the stress-responsive Transcription Factor EB [PDF]

Autophagy Reports, 2022
TFEBexplorer is a comprehensive web-tool to study genes modulated by the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, that integrates multiple datasets following genetic perturbation of TFEB with ...
Rossella De Cegli, Diego Carrella, Diletta Siciliano, Gennaro Gambardella, Gennaro Napolitano, Chiara Di Malta, Andrea Ballabio, Diego di Bernardo   +7 more
doaj   +2 more sources

Cadmium targeting transcription factor EB to inhibit autophagy-lysosome function contributes to acute kidney injury [PDF]

Journal of Advanced Research
Introduction: Environmental and occupational exposure to cadmium (Cd) has been shown to cause acute kidney injury (AKI). Previous studies have demonstrated that autophagy inhibition and lysosomal dysfunction are important mechanisms of Cd-induced AKI ...
Peng-Fei Dong, Tian-Bin Liu, Kai Chen, Dan Li, Yue Li, Cai-Yu Lian, Zhen-Yong Wang, Lin Wang   +7 more
doaj   +2 more sources

Enhancement of lysosome biogenesis as a potential therapeutic approach for neurodegenerative diseases

Neural Regeneration Research, 2023
Millions of people are suffering from Alzheimer’s disease globally, but there is still no effective treatment for this neurodegenerative disease. Thus, novel therapeutic approaches for Alzheimer’s disease are needed, which requires further evaluation of ...
Wenlong Xue, Jie Zhang, Yang Li
doaj   +1 more source

Tubastatin A Improves Post‐Resuscitation Myocardial Dysfunction by Inhibiting NLRP3‐Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Myocardial dysfunction is the leading cause of early death following successful cardiopulmonary resuscitation (CPR) in people with cardiac arrest (CA), which is potentially driven by cell pyroptosis mediated by NOD‐like receptor pyrin domain 3
Jiefeng Xu, Xue Zhao, Xiangkang Jiang, Lu He, Xinjie Wu, Jiangang Wang, Qijiang Chen, Yulin Li, Mao Zhang   +8 more
doaj   +1 more source

Resveratrol Attenuates Oxalate-Induced Renal Oxidative Injury and Calcium Oxalate Crystal Deposition by Regulating TFEB-Induced Autophagy Pathway

Frontiers in Cell and Developmental Biology, 2021
The oxidative injury of renal tubular epithelial cells caused by inflammation and oxidative stress induced by hyperoxaluria is an important factor in the kidney calcium oxalate (CaOx) stone formation.
Yue Wu, Yue Wu, Yang Xun, Yang Xun, Jiaqiao Zhang, Jiaqiao Zhang, Henglong Hu, Henglong Hu, Baolong Qin, Baolong Qin, Tao Wang, Tao Wang, Shaogang Wang, Shaogang Wang, Cong Li, Cong Li, Yuchao Lu, Yuchao Lu   +17 more
doaj   +1 more source

Multifaceted activities of transcription factor EB in cancer onset and progression

Molecular Oncology, 2021
Transcription factor EB (TFEB) represents an emerging player in cancer biology. Together with microphthalmia‐associated transcription factor, transcription factor E3 and transcription factor EC, TFEB belongs to the microphthalmia family of bHLH‐leucine ...
Elena Astanina, Federico Bussolino, Gabriella Doronzo   +2 more
doaj   +1 more source

Blockage of Extracellular Signal-Regulated Kinase Exerts an Antitumor Effect via Regulating Energy Metabolism and Enhances the Efficacy of Autophagy Inhibitors by Regulating Transcription Factor EB Nuclear Translocation in Osteosarcoma

Frontiers in Cell and Developmental Biology, 2021
Accumulating evidence suggests that extracellular signal-regulated kinase (ERK) is a valuable target molecule for cancer. However, antitumor drugs targeting ERK are still in their clinical phase and no FDA-approved medications exist.
Man Zhang, Man Zhang, Man Zhang, Yang Bai, Chang Xu, Yiying Qi, Jiahong Meng, Wenkan Zhang, Hang Su, Weiqi Yan, Weiqi Yan, Weiqi Yan   +11 more
doaj   +1 more source

RNA Sequencing Reveals the Alteration of the Expression of Novel Genes in Ethanol-Treated Embryoid Bodies. [PDF]

PLoS ONE, 2016
Fetal alcohol spectrum disorder is a collective term representing fetal abnormalities associated with maternal alcohol consumption. Prenatal alcohol exposure and related anomalies are well characterized, but the molecular mechanism behind this phenomenon
Chanchal Mandal, Sun Hwa Kim, Jin Choul Chai, Seon Mi Oh, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai   +6 more
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Research Hotspots and Trends Analysis of TFEB: A Bibliometric and Scientometric Analysis

Frontiers in Molecular Neuroscience, 2022
ObjectiveTo explore the development context, research hotspots and frontiers of Transcription factor EB (TFEB) from 1991 to 2021 by bibliometric analysis.MethodsPublications about TFEB research from 1991 to 2021 were retrieved from the Web of Science ...
Runjin Zhou, Xiaoling Lin, Xiaoling Lin, Dongmin Liu, Zhao Li, Jingchun Zeng, Xingdong Lin, Xiaodi Liang   +7 more
doaj   +1 more source

TFEB overexpression promotes glycogen clearance of Pompe disease iPSC-derived skeletal muscle

Molecular Therapy: Methods & Clinical Development, 2016
Pompe disease (PD) is a lysosomal disorder caused by acid α-glucosidase (GAA) deficiency. Progressive muscular weakness is the major symptom of PD, and enzyme replacement therapy can improve the clinical outcome.
Yohei Sato, Hiroshi Kobayashi, Takashi Higuchi, Yohta Shimada, Hiroyuki Ida, Toya Ohashi   +5 more
doaj   +1 more source