Results 21 to 30 of about 4,631,251 (249)

Bayesian model-based inference of transcription factor activity [PDF]

, 2007
<b>Background:</b> In many approaches to the inference and modeling of regulatory interactions using microarray data, the expression of the gene coding for the transcription factor is considered to be an accurate surrogate for the true ...
Rogers, S, Girolami, M, Rogers, Simon, Girolami, Mark, Khanin, R, Khanin, Raya   +5 more
core   +1 more source

TFEB overexpression promotes glycogen clearance of Pompe disease iPSC-derived skeletal muscle

Molecular Therapy: Methods & Clinical Development, 2016
Pompe disease (PD) is a lysosomal disorder caused by acid α-glucosidase (GAA) deficiency. Progressive muscular weakness is the major symptom of PD, and enzyme replacement therapy can improve the clinical outcome.
Yohei Sato, Hiroshi Kobayashi, Takashi Higuchi, Yohta Shimada, Hiroyuki Ida, Toya Ohashi   +5 more
doaj   +1 more source

An R2R3 MYB transcription factor associated with regulation of the anthocyanin biosynthetic pathway in Rosaceae [PDF]

, 2010
Background The control of plant anthocyanin accumulation is via transcriptional regulation of the genes encoding the biosynthetic enzymes. A key activator appears to be an R2R3 MYB transcription factor.
Wang, Kui-Lin, Kortstee, A.J., Tony K McGhie, McGhie Tony K, Hellens, R.P., Espley Richard V, Hellens Roger P, Grafton, Karryn, Espley, Richard V., Karryn Grafton, Karunairetnam, Sakuntala, Andrew C Allan, Kortstee, Anne, Roger P Hellens, Allan, A.C., Allan, Andrew C., McGhie, T.K., Richard V Espley, Kortstee Anne, Allan Andrew C, Espley, R.V., Sakuntala Karunairetnam, Karunairetnam Sakuntala, Grafton Karryn, McGhie, Tony K., Lin-Wang Kui, Bolitho, Karen, Karen Bolitho, Anne Kortstee, Bolitho Karen, Hellens, Roger P., Lin-Wang, Kui, Kui Lin-Wang   +32 more
core   +2 more sources

Variable structure motifs for transcription factor binding sites [PDF]

, 2010
Background: Classically, models of DNA-transcription factor binding sites (TFBSs) have been based on relatively few known instances and have treated them as sites of fixed length using position weight matrices (PWMs).
Evans, Kenneth J., Dyer, N., Nigel Dyer, Ott Sascha, Reid, J.E., Lorenz Wernisch, Sascha Ott, Ott, S., Wernisch Lorenz, John E Reid, Evans Kenneth J, Wernisch, Lorenz, Reid, J. E. (John E.), Kenneth J Evans, Dyer, Nigel, Dyer Nigel, Ott, Sascha, Reid John E   +17 more
core   +6 more sources

Transcription factor E3 renal cell carcinoma presenting as secondary hypertension

Current Urology, 2023
. Microphthalmia-associated transcription factor family (transcription factor E3 or transcription factor EB) translocation renal cell carcinomas (RCCs) are rare neoplasms.
Alain Mwamba Mukendi, Gerald Tatenda Mataruka, Ramesh Nadimpalli, Tshisola Miji Kasapato   +3 more
doaj   +1 more source

Using temporal correlation in factor analysis for reconstructing transcription factor activities [PDF]

, 2008
Two-level gene regulatory networks consist of the transcription factors (TFs) in the top level and their regulated genes in the second level. The expression profiles of the regulated genes are the observed high-throughput data given by experiments such ...
Wernisch, Lorenz, Lorenz Wernisch, Pournara, Iosifina, Iosifina Pournara   +3 more
core   +1 more source

Turnover and function of DNA methylation at transcription factor binding sites [PDF]

, 2014
Cell type identity is largely determined by regulatory networks consistent of various transcription factors. Transcription factor activity requires interaction with DNA and thus critically depends on the accessibility of binding motifs.
Feldmann, Angelika
core   +1 more source

The membrane-tethered transcription factor ANAC089 serves as redox-dependent suppressor of stromal ascorbate peroxidase gene expression [PDF]

, 2012
Klein P, Seidel T, Stöcker B, Dietz K-J. The membrane-tethered transcription factor ANAC089 serves as redox-dependent suppressor of stromal ascorbate peroxidase gene expression. Frontiers in Plant Science.
Thorsten Seidel, Dietz, Karl-Josef, Benedikt eStöcker, Benedikt Stöcker, Peter eKlein, Klein, Peter, Thorsten eSeidel, Peter Klein, Karl-Josef Dietz, Seidel, Thorsten, Stöcker, Benedikt, Karl-Josef eDietz   +11 more
core   +1 more source

The TFEB-TGIF1 axis regulates EMT in mouse epicardial cells

Nature Communications, 2022
Epithelial-mesenchymal transition (EMT) is a complex process involved in organogenesis. Here, the authors show that the transcription factor EB (TFEB) regulates EMT in epicardium during heart development by tuning sensitivity to TGFβ signaling.
Elena Astanina, Gabriella Doronzo, Davide Corà, Francesco Neri, Salvatore Oliviero, Tullio Genova, Federico Mussano, Emanuele Middonti, Edoardo Vallariello, Chiara Cencioni, Donatella Valdembri, Guido Serini, Federica Limana, Eleonora Foglio, Andrea Ballabio, Federico Bussolino   +15 more
doaj   +1 more source

Functional analysis of the competence transcription factor ComK of Bacillus subtilis by characterization of truncation variants [PDF]

, 2005
The competence transcription factor ComK is the master regulator of competence development in Bacillus subtilis. In the regulatory pathway, ComK is involved in different interactions: (i) protein–DNA interactions to stimulate transcription of ComK ...
Andy-Mark W. H. Thunnissen, Thunnissen, Andy-Mark W.H.,, Thunnissen, A.M.W.H.; id_orcid, Oscar P. Kuipers, Fusetti, F., Fabrizia Fusetti, Hamoen, L.W, Susanna, Kim, Kim A. Susanna, Susanna, Kim Amé,, Kuipers, Oscar P.,, Susanna, Kim A.,, Fusetti, Fabrizia,, Kuipers, O.P., Hamoen, Leendert W.,, Susanna, Kim Amé, Kuipers, O.P.; id_orcid, Thunnissen, A.M.W.H., Leendert W. Hamoen   +18 more
core   +2 more sources