Results 91 to 100 of about 15,357 (224)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Small-molecule activation of TFEB alleviates Niemann–Pick disease type C via promoting lysosomal exocytosis and biogenesis

eLife
Niemann–Pick disease type C (NPC) is a devastating lysosomal storage disease characterized by abnormal cholesterol accumulation in lysosomes. Currently, there is no treatment for NPC.
Kaili Du, Hongyu Chen, Zhaonan Pan, Mengli Zhao, Shixue Cheng, Yu Luo, Wenhe Zhang, Dan Li   +7 more
doaj   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation

Frontiers in Cell and Developmental Biology, 2019
Ubiquitin-proteasome pathway (UPS) and autophagy-lysosome pathway (ALP) are the two major protein degradation pathways, which are critical for proteostasis.
Chunyan Li, Chunyan Li, Chunyan Li, Xin Wang, Xin Wang, Xuezhi Li, Xuezhi Li, Kaixin Qiu, Kaixin Qiu, Kaixin Qiu, Fengjuan Jiao, Fengjuan Jiao, Yidan Liu, Qingxia Kong, Yan Liu, Yan Liu, Yili Wu, Yili Wu   +17 more
doaj   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Liquiritigenin Ameliorates High‐Fat Diet‐Induced Hepatic Steatosis by Promoting Lipid Droplet Catabolism via PLIN2‐ATGL Regulation

Phytotherapy Research, EarlyView.
Liquiritigenin promotes expression of CGI‐58 and enhances lipolysis by down‐regulating expression of PLIN2, thereby facilitating the catabolism of larger‐sized lipid droplets and producing smaller‐sized lipid droplets, resulting in enhanced activity of lipophagy and ameliorated hepatic steatosis. ABSTRACT Metabolic‐associated fatty liver disease (MAFLD)
Zhuoya Xu, Jingmiao Chen, Hong Qin, Yansong Fu, Cunqi Lv, Zhipeng Wang, Xi Liu, Wenya Zheng   +7 more
wiley   +1 more source

MITF and TFEB cross-regulation in melanoma cells

PLOS ONE, 2020
The MITF, TFEB, TFE3 and TFEC (MiT-TFE) proteins belong to the basic helix-loop-helix family of leucine zipper transcription factors. MITF is crucial for melanocyte development and differentiation, and has been termed a lineage-specific oncogene in melanoma. The three related proteins MITF, TFEB and TFE3 have been shown to be involved in the biogenesis
Ballesteros-Álvarez, Josué, Dilshat, Ramile, Fock, Valerie, Möller, Katrín, Karl, Ludwig, Larue, Lionel, Ögmundsdóttir, Margrét Helga, Steingrímsson, Eiríkur   +7 more
openaire   +6 more sources

Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis

, 2018
Rationale: Postischemic angiogenesis is critical to limit the ischemic tissue damage and improve the blood flow recovery.
Haocheng Lu, Minerva T. Garcia-Barrio, Yanbo Fan, Yibai Hao, Y. Eugene Chen, Yanhong Guo, Tianqing Zhu, Wenying Liang, Ji Zhang, Jifeng Zhang   +9 more
core   +1 more source

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

Nature Communications
Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and cellular clearance pathways. TFEB activity is tightly controlled by multiple post-translational mechanisms, but the exact molecular mechanism controlling its stability has ...
Yan Xiong, Jaiprakash Sharma, Meggie N. Young, Wen Xiong, Ali Jazayeri, Karl F. Poncha, Ma. Xenia G. Ilagan, Qing Wang, Bei Gao, Hui Zheng, Nicolas L. Young, Marco Sardiello   +11 more
doaj   +1 more source

Multi‐Target Pharmacological Mechanisms of Salvia miltiorrhiza Bunge in Metabolic Syndrome and Cardiovascular Diseases: A Comprehensive Review Based on the Theory of “Same Treatment for Different Diseases”

Phytotherapy Research, EarlyView.
Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia, Kaiyi Wu, Jiaying Qi, Nana Huang, Yusheng Liu, Xiumei Gao, Rong Sun   +6 more
wiley   +1 more source