Results 71 to 80 of about 15,357 (224)

Regulation of TFEB and TFE3 activity in skeletal muscle remodeling [PDF]

, 2022
Muscle is a highly dynamic and plastic tissue that adapts to varying loading conditions by changes in muscle mass and fiber type composition. Muscle mass is mainly regulated by changes in protein synthesis and protein degradation.
Pablo Tortola, Cristina
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Obesity-related proximal tubulopathy: an emerging threat to kidney health

Autophagy Reports, 2023
Our previous studies have demonstrated that lipid overload leads to lysosomal dysfunction and autophagic stagnation in kidney proximal tubular epithelial cells (PTECs), which contributes to the renal lipotoxicity and eventually leading to the development
Takeshi Yamamoto, Jun Nakamura, Yoshitsugu Takabatake, Yoshitaka Isaka   +3 more
doaj   +1 more source

Metformin Alleviates Hepatic Steatosis and Insulin Resistance in a Mouse Model of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Promoting Transcription Factor EB-Dependent Autophagy

Frontiers in Pharmacology, 2021
Nonalcoholic fatty liver disease (NAFLD) results from an abnormal accumulation of lipids within hepatocytes, and is commonly associated with obesity, insulin resistance, and hyperlipidemia. Metformin is commonly used to treat type 2 diabetes mellitus and,
Dan Zhang, Yicheng Ma, Jianjun Liu, Yi Deng, Bo Zhou, Yu Wen, Mingke Li, Daiyan Wen, Yunyan Ying, Sufeng Luo, Chunjing Shi, Guangyu Pu, Yinglei Miao, Chenggang Zou, Yuanli Chen, Lanqing Ma   +15 more
doaj   +1 more source

Surviving starvation simply without TFEB

PLOS Biology, 2019
Starvation is among the most ancient of selection pressures, driving evolution of a robust arsenal of starvation survival defenses. In order to survive starvation stress, organisms must be able to curtail anabolic processes during starvation and judiciously activate catabolic pathways.
Alexander A. Soukas, Ben Zhou
openaire   +4 more sources

mTOR-dependent phosphorylation controls TFEB nuclear export

, 2018
The transcriptional activation of catabolic processes during starvation is induced by the nuclear translocation and consequent activation of transcription factor EB (TFEB), a master modulator of autophagy and lysosomal biogenesis.
Gennaro Napolitano, Andrea Ballabio, Valerio Benedetti, Diego Luis Medina, Jennifer Lippincott-Schwartz, Jlenia Monfregola, Maria Matarese, Heejun Choi, Alessandra Esposito, Chiara Di Malta   +9 more
core   +2 more sources

TFEB nuclear translocation after serum starvation.

, 2023
A. HT and NPC1 mutant fibroblasts immunolabeled with TFEB and DAPI showing nuclear translocation of TFEB after 24hrs of SSM. Scale bar: (A) 30 μm. (TIF)
Lindsay Walsh (17512400), Claude Krummenacher (203338), Sarah Kim (42142), Ileana Soto (531878), Collin M. MacLeod (17512385), Zerian D. Barrera (17512397), Benjamin Carone (17512403), Fawad A. K. Yousufzai (17512388), Liam T. Spencer (17512391), Lucianne A. Rivera-Rosario (17512394)   +9 more
core   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source