Results 21 to 30 of about 15,357 (224)
, 2015 The general view of the lysosome as the terminal end of cellular catabolic pathways, has started to change due to the recent discoveries of a lysosomal nutrient sensing machinery and of a lysosome-to-nucleus signaling mechanism that modulate lysosomal function by way of the master transcriptional regulator TFEB.
SETTEMBRE, CARMINE +2 more
openaire +4 more sources
USP7 protects TFEB from proteasome-mediated degradation
Cell ReportsSummary: The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and autophagy. We identify a distinct nuclear interactome of TFEB, with ubiquitin-specific protease 7 (USP7) emerging as a key post-translational modulator of TFEB.
Swati Keshri +3 more
doaj +3 more sources
Multistep regulation of TFEB by MTORC1 [PDF]
Autophagy, 2017 The master regulator of lysosome biogenesis, TFEB, is regulated by MTORC1 through phosphorylation at S211, and a S211A mutation increases nuclear localization. However, TFEBS211A localizes diffusely in both cytoplasm and nucleus and, as we show, retains regulation by MTORC1.
Vega-Rubín-de-Celis, Silvia +3 more
openaire +4 more sources
Protein and Cell, 2016 Microglia play a pivotal role in clearance of Aβ by degrading them in lysosomes, countering amyloid plaque pathogenesis in Alzheimer’s disease (AD). Recent evidence suggests that lysosomal dysfunction leads to insufficient elimination of toxic protein ...
Xuyang Zhao, Chen Zhang
exaly +3 more sources
TFEB (transcription factor EB) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on TFEB (transcription factor EB), with data on DNA, on the protein encoded, and where the gene is implicated.
Kuiper, RP
openaire +2 more sources
Journal of Advanced ResearchIntroduction: β-Elemene (β-ELE), derived from Curcuma wenyujin, has anticancer effect on non-small cell lung cancer (NSCLC). However, the potential target and detail mechanism were still not clear.
Jian-Shu Lou, Li-Ping Zhao, Hao-Jie Wang
exaly +3 more sources
Disrupted TFEB/GDNF-cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice. [PDF]
Adv Sci (Weinh)ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Yao L +5 more
europepmc +2 more sources
Huntingtin Aggregate-Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice. [PDF]
Adv Sci (Weinh)CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Zhu J +8 more
europepmc +2 more sources
Autophagy and liver cancer [PDF]
Clinical and Molecular Hepatology, 2020 Autophagy is a highly conserved catabolic process that degrades cytosolic proteins and organelles via formation of autophagosomes that fuse with lysosomes to form autolysosomes, whereby autophagic cargos are degraded.
Xiaojuan Chao +4 more
doaj +1 more source
ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function. [PDF]
Adv Sci (Weinh)In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Liu X +7 more
europepmc +2 more sources