Results 31 to 40 of about 15,357 (224)

TFEB

Current Biology, 2023
Contreras and Puertollano introduce TFEB, a transcription factor that orchestrates cellular responses to stress via mechanisms including upregulation of lysosome biogenesis and autophagy.
Pablo S, Contreras, Rosa, Puertollano
openaire   +3 more sources

Silent information regulator 3 modulates lysosome function to inhibit apoptosis of U87 cell by mTOR pathway

陆军军医大学学报, 2023
Objective To investigate the role of silent information regulator 3 (Sirt3) in glioma U87 cells, and provide new targets for early diagnosis and treatment of glioma.
ZHANG Xudong, ZHANG Xudong, SHAN Litianyi, WANG Rong   +3 more
doaj   +1 more source

TFEBexplorer: An integrated tool to study genes regulated by the stress-responsive Transcription Factor EB

Autophagy Reports, 2022
TFEBexplorer is a comprehensive web-tool to study genes modulated by the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, that integrates multiple datasets following genetic perturbation of TFEB with ...
Rossella De Cegli, Diego Carrella, Diletta Siciliano, Gennaro Gambardella, Gennaro Napolitano, Chiara Di Malta, Andrea Ballabio, Diego di Bernardo   +7 more
doaj   +1 more source

Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagy

Autophagy Reports, 2023
Intracellular pathogens establish persistent infections by generating reservoirs that protect them from the action of antibiotics and the host immune response.
Mariana I. Capurro, Akriti Prashar, Xiaodong Gao, Nicola L. Jones   +3 more
doaj   +1 more source

TFEB [PDF]

Autophagy, 2013
Parkinson disease (PD) is characterized by the progressive loss of nigral dopamine neurons and the presence of accumulations containing the disease-causing protein SNCA/α-synuclein. Here we review our recent findings describing how SNCA impairs the function of the master regulator of the autophagy-lysosomal pathway (ALP), the transcription factor EB ...
Mickael, Decressac, Anders, Björklund
openaire   +2 more sources

TFEB- and TFE3-dependent autophagy activation supports cancer proliferation in the absence of centrosomes

, 2022
Centrosome amplification is a phenomenon frequently observed in human cancers, so centrosome depletion has been proposed as a therapeutic strategy. However, despite being afflicted with a lack of centrosomes, many cancer cells can still proliferate ...
Xin-Ying Lu (12275041), Chien-Han Kao (563248), Chien-Yung Huang (12275044), Hung-Hsiang Huang (12275047), Wann-Neng Jane (502703), Won-Jing Wang (12275050), Wei-Syun Huang (12275038), Ting-Yu Su (10291104)   +7 more
core   +1 more source

TFEB Promotes Prostate Cancer Progression via Regulating ABCA2-Dependent Lysosomal Biogenesis

Frontiers in Oncology, 2021
Transcription factor EB (TFEB), a member of the MiT family, is dysregulated in different cancers and exerts specific biological functions within the tumor microenvironment.
Xuejin Zhu, Xuejin Zhu, Yangjia Zhuo, Shulin Wu, Shulin Wu, Yanfei Chen, Jianheng Ye, Yulin Deng, Yuanfa Feng, Ren Liu, Shanghua Cai, Zhihao Zou, Bin Wang, Chin-Lee Wu, Chin-Lee Wu, Guohua Zeng, Weide Zhong, Weide Zhong, Weide Zhong   +18 more
doaj   +1 more source

Oxidative Stress Induces Neuronal Apoptosis Through Suppressing Transcription Factor EB Phosphorylation at Ser467

Cellular Physiology and Biochemistry, 2018
Background/Aims: This study determined the role and mechanism of action of transcription factor EB (TFEB) in H2O2-induced neuronal apoptosis. Methods: SH-SY5Y cells were treated with Akt inhibitor/activator and different concentrations of H2O2.
Qian Su, Bin Zheng, Chen-yao Wang, Yun-zhi Yang, Wen-wen Luo, Shu-min Ma, Xin-hua Zhang, Dong Ma, Yan Sun, Zhan Yang, Jin-kun Wen, Zhi-xue Liu   +11 more
doaj   +1 more source

TFEB regulates pluripotency transcriptional network in mouse embryonic stem cells independent of autophagy–lysosomal biogenesis

Cell Death and Disease, 2021
Transcription factor EB (TFEB), a well-known master regulator of autophagy and lysosomal biogenesis, is a member of the microphthalmia family of transcription factors (MiT family).
Anderson Tan, Renuka Prasad, Eek-hoon Jho   +2 more
doaj   +1 more source

TFEB Links Autophagy to Lysosomal Biogenesis [PDF]

Science, 2011
Starvation activates a transcriptional program controlling autophagosome formation, lysosome fusion, and substrate degradation.
Settembre C., Di Malta C., Polito V. A., Arencibia M. G., Vetrini F., Erdin S., Erdin S. U., Huynh T., Medina Sanabria DL., Colella P., Sardiello M., Rubinsztein D. C., Ballabio A.   +12 more
openaire   +4 more sources